AMD risk has dropped by birth cohort throughout 20th century

November 19, 2017

(HealthDay)—There was a decrease in the five-year risk for age-related macular degeneration (AMD) by birth cohorts throughout the 20th century, according to a study published online Nov. 16 in JAMA Ophthalmology.

Karen J. Cruickshanks, Ph.D., from the University of Wisconsin-Madison, and colleagues examined data from the longitudinal cohort Beaver Dam Eye Study and the Beaver Dam Offspring Study. Data were included for 4,819 adults at risk for developing AMD based on fundus images obtained at baseline visits.

The researchers found that the five-year age- and sex-adjusted incidence of AMD was 8.8, 3, 1, and 0.3 percent in the Greatest Generation (born 1901 to 1924), the Silent Generation (born 1925 to 1945), the Baby Boom Generation (born 1946 to 1964), and Generation X (born 1965 to 1984). Each was more than 60 percent less likely to develop AMD than the previous generation after adjustment for age and sex (relative risk, 0.34). After adjustment for multiple confounding variables—including age; sex; smoking; educational attainment; exercise; levels of non-high-density-lipoprotein cholesterol and high-sensitivity C-reactive protein; and use of , statins, and multivitamins—the generational association remained significant (relative risk, 0.4).

"Factors that explain this decline in risk are not known," the authors write. "However, this pattern is consistent with reported declines in risks for cardiovascular disease and dementia, suggesting that aging Baby Boomers may experience better retinal health at older ages than did previous generations."

Explore further: Mental wellbeing of generation X directly linked to childhood 

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Related Stories

Mental wellbeing of generation X directly linked to childhood 

October 26, 2017
Childhood disadvantage is strongly associated with poorer adult mental wellbeing for generation X, according to a UCL study.

Generation X at greater risk of stroke than baby boomers, study finds

November 23, 2016
Older baby boomers—those born between 1945 and 1954—can proudly boast a new label: the "stroke-healthiest generation," according to a Rutgers study that found the lowest incidence of ischemic stroke in this age group ...

Intergenerational recurrence of retained placenta observed

July 27, 2017
(HealthDay)—Intergenerational recurrence of retained placenta is seen on the maternal and paternal side, according to a study published online July 21 in BJOG: An International Journal of Obstetrics and Gynaecology.

Is dementia declining among older Americans?

September 5, 2017
(HealthDay)—Here's some good news for America's seniors: The rates of Alzheimer's and other forms of dementia have dropped significantly over the last decade or so, a new study shows.

The adult generations of today are less healthy than their counterparts of previous generations

April 10, 2013
Sophia Antipolis, 10 April 2013. Despite their greater life expectancy, the adults of today are less "metabolically" healthy than their counterparts of previous generations. That's the conclusion of a large cohort study from ...

Recommended for you

Newly published research provides new insight into how diabetes leads to retinopathy

December 7, 2017
An international team of scientists led by Professor Ingrid Fleming of Goethe University, Frankfurt, Germany, and including Professor Bruce Hammock of the University of California, Davis, provides new insight into the mechanism ...

Researchers use breakthrough technology to understand eclipse eye damage

December 7, 2017
In a first-of-its-kind study, Mount Sinai researchers are using adaptive optics (AO) to analyze retinal eye damage from the August solar eclipse on a cellular level. The research could help doctors develop a deeper understanding ...

Combating eye injuries with a reversible superglue seal

December 6, 2017
When a soldier sustains a traumatic eye injury on the battlefield, any delay in treatment may lead to permanent vision loss. With medical facilities potentially far away and no existing tools to prevent deterioration, medics ...

Trigger for most common form of vision loss discovered

November 27, 2017
In a major step forward in the battle against macular degeneration, the leading cause of vision loss among the elderly, researchers at the University of Virginia School of Medicine have discovered a critical trigger for the ...

Scientists engineer drug delivery device that treats glaucoma directly inside the eye

November 23, 2017
Glaucoma, which affects over 60 million people worldwide, can seem easy to treat: medicated eye drops can be used to ease the buildup of fluid in the eye that underlies the condition. If glaucoma is caught early, eye drops ...

Research reveals biological mechanism of a leading cause of childhood blindness

November 16, 2017
Scientists at the Virginia Tech Carilion Research Institute (VTCRI) have revealed the pathology of cells and structures stricken by optic nerve hypoplasia, a leading cause of childhood blindness in developed nations.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.