AMD risk has dropped by birth cohort throughout 20th century

November 19, 2017

(HealthDay)—There was a decrease in the five-year risk for age-related macular degeneration (AMD) by birth cohorts throughout the 20th century, according to a study published online Nov. 16 in JAMA Ophthalmology.

Karen J. Cruickshanks, Ph.D., from the University of Wisconsin-Madison, and colleagues examined data from the longitudinal cohort Beaver Dam Eye Study and the Beaver Dam Offspring Study. Data were included for 4,819 adults at risk for developing AMD based on fundus images obtained at baseline visits.

The researchers found that the five-year age- and sex-adjusted incidence of AMD was 8.8, 3, 1, and 0.3 percent in the Greatest Generation (born 1901 to 1924), the Silent Generation (born 1925 to 1945), the Baby Boom Generation (born 1946 to 1964), and Generation X (born 1965 to 1984). Each was more than 60 percent less likely to develop AMD than the previous generation after adjustment for age and sex (relative risk, 0.34). After adjustment for multiple confounding variables—including age; sex; smoking; educational attainment; exercise; levels of non-high-density-lipoprotein cholesterol and high-sensitivity C-reactive protein; and use of , statins, and multivitamins—the generational association remained significant (relative risk, 0.4).

"Factors that explain this decline in risk are not known," the authors write. "However, this pattern is consistent with reported declines in risks for cardiovascular disease and dementia, suggesting that aging Baby Boomers may experience better retinal health at older ages than did previous generations."

Explore further: Mental wellbeing of generation X directly linked to childhood 

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Related Stories

Mental wellbeing of generation X directly linked to childhood 

October 26, 2017
Childhood disadvantage is strongly associated with poorer adult mental wellbeing for generation X, according to a UCL study.

Generation X at greater risk of stroke than baby boomers, study finds

November 23, 2016
Older baby boomers—those born between 1945 and 1954—can proudly boast a new label: the "stroke-healthiest generation," according to a Rutgers study that found the lowest incidence of ischemic stroke in this age group ...

Intergenerational recurrence of retained placenta observed

July 27, 2017
(HealthDay)—Intergenerational recurrence of retained placenta is seen on the maternal and paternal side, according to a study published online July 21 in BJOG: An International Journal of Obstetrics and Gynaecology.

Is dementia declining among older Americans?

September 5, 2017
(HealthDay)—Here's some good news for America's seniors: The rates of Alzheimer's and other forms of dementia have dropped significantly over the last decade or so, a new study shows.

The adult generations of today are less healthy than their counterparts of previous generations

April 10, 2013
Sophia Antipolis, 10 April 2013. Despite their greater life expectancy, the adults of today are less "metabolically" healthy than their counterparts of previous generations. That's the conclusion of a large cohort study from ...

Recommended for you

Microglia protect sensory cells needed for vision after retinal detachment

June 18, 2018
A research team at Massachusetts Eye and Ear has shown that microglia, the primary immune cells of the brain and retina, play a protective role in response to retinal detachment. Retinal detachment and subsequent degeneration ...

161 genetic factors for myopia identified

June 15, 2018
The international Consortium for Refractive Error and Myopia (CREAM) recently published the largest-ever genetic study of myopia in Nature Genetics. Researchers from the Gutenberg Health Study at the Medical Center of Johannes ...

Normal eye dominance is not necessary for restoring visual acuity in amblyopia

June 7, 2018
Amblyopia, commonly known as "lazy eye," is a visual disorder common in children. The symptoms often are low acuity in the affected or "lazy" eye and impaired depth perception. Researchers have long believed that the impaired ...

Education linked to higher risk of short-sightedness

June 6, 2018
Spending more years in full time education is associated with a greater risk of developing short-sightedness (myopia), finds a study published by The BMJ today.

First 3D-printed human corneas

May 29, 2018
The first human corneas have been 3-D printed by scientists at Newcastle University, UK.

Satellite imaging techniques may help reduce preventable vision loss

May 11, 2018
By adapting pattern recognition techniques used to assess satellite images, scientists have devised a novel way to diagnose blinding eye diseases, such as age-related macular degeneration.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.