Clinician suspicion minimally accurate for Lyme disease

November 27, 2017

(HealthDay)—Clinician suspicion has minimal accuracy for the diagnosis of Lyme disease, according to a study published online Nov. 24 in Pediatrics.

Lise E. Nigrovic, M.D., M.P.H., from the Boston Children's Hospital, and colleagues assembled a prospective cohort of children aged 1 to 21 years evaluated for Lyme to examine the accuracy of clinician suspicion. Treating physicians were asked to estimate the probability of Lyme disease, and the ability of clinician suspicion to diagnose Lyme disease was calculated as the area under the curve for the receiver operating curve. Lyme disease was defined as a patient with an erythema migrans lesion or positive two-tiered serology results for patients with compatible symptoms.

Overall, 1,021 children were enrolled, of whom, 23 percent had Lyme disease. The researchers found that clinician suspicion had a minimal ability to differentiate children with and without Lyme disease (area under the curve, 0.75). Twelve percent of the 554 who the treating clinicians thought were unlikely to have Lyme disease had Lyme disease, and 31 percent of those who the treating thought were very likely to have Lyme disease did not have Lyme disease.

"Because clinician suspicion had only minimal accuracy for the diagnosis of Lyme disease, laboratory confirmation is required to avoid both under- and over-diagnosis," the authors write.

Explore further: Chronic Lyme disease treatments tied to serious adverse effects

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Chronic Lyme disease treatments tied to serious adverse effects

June 20, 2017
(HealthDay)—Serious bacterial infections have been documented during treatment for chronic Lyme disease, according to research published in the June 16 issue of the U.S. Centers for Disease Control and Prevention's Morbidity ...

Lyme disease 'Biofilm' eludes antibiotics: report

February 25, 2016
(HealthDay)—The bacteria that causes Lyme disease protects itself from antibiotics by forming a slime-like layer called a biofilm, a new study shows.

'Water on the knee' could be early sign of Lyme disease

November 1, 2015
Spontaneous knee effusion, also known as "water on the knee," can be a primary symptom of Lyme disease, even when patients do not exhibit a "bull's eye" rash, another common Lyme disease symptom. According to a literature ...

New Lyme disease estimate: 300,000 cases a year

August 19, 2013
Health officials say Lyme disease is about 10 times more common than previously reported.

New national Lyme Disease biobank to accelerate research by making samples available

January 24, 2017
Bay Area Lyme Foundation, a national organization funding research to make Lyme disease easy to diagnose and simple to cure, announces the launch of the Lyme Disease Biobank, which is the first program to provide researchers ...

No Lyme disease in Australia, new research finds

October 31, 2016
Lyme disease cannot be contracted in Australia and patients should not be treated with antibiotics for so-called Lyme-like diseases, new medical research has found.

Recommended for you

PET scans to optimize tuberculosis meningitis treatments and personalize care, study finds

December 6, 2018
Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain—or tuberculosis meningitis (TBM)—is often deadly, always hard to treat, and a particular ...

Silicosis is on the rise, but is there a therapeutic target?

December 6, 2018
Researchers from the CNRS, the University of Orléans, and the company Artimmune, in collaboration with Turkish clinicians from Atatürk University, have identified a key mechanism of lung inflammation induced by silica exposure, ...

Infectivity of different HIV-1 strains may depend on which cell receptors they target

December 6, 2018
Distinct HIV-1 strains may differ in the nature of the CCR5 molecules to which they bind, affecting which cells they can infect and their ability to enter cells, according to a study published December 6 in the open-access ...

Protecting cell powerhouse paves way to better treatment of acute kidney injury

December 6, 2018
For the first time, scientists have described the body's natural mechanism for temporarily protecting the powerhouses of kidney cells when injury or disease means they aren't getting enough blood or oxygen.

New study uncovers why Rift Valley fever is catastrophic to developing fetuses

December 5, 2018
Like Zika, infection with Rift Valley fever virus can go unnoticed during pregnancy, all the while doing irreparable—often lethal—harm to the fetus. The results of a new study, led by researchers at the University of ...

Study highlights potential role of bioaerosol sampling to address airborne biological threats

December 5, 2018
As a leading global city with a high population density, Singapore is vulnerable to the introduction of biological threats. Initiating an early emergency response to such threats calls for the rapid identification of the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.