Higher β-blocker dose linked to lower mortality risk

November 21, 2017

(HealthDay)—An increased β-blocker dose is associated with a greater prognostic advantage in patients with chronic heart failure (CHF) and diabetes than in those with CHF but no diabetes, according to a study published online Oct. 25 in Diabetes Care.

Klaus K. Witte, M.D., from the University of Leeds in the United Kingdom, and colleagues assessed the impact of β-blockers and angiotensin-converting enzyme inhibitors (ACEIs) on mortality in CHF patients with and without in a . They recruited 1,797 patients with CHF from 2006 to 2014, and mean follow-up was four years.

The researchers found that patients with diabetes were prescribed larger doses of β-blockers and ACEIs compared to patients without diabetes. Lower mortality was seen with increasing β-blocker dose in both patients with diabetes (8.9 percent per mg/day) and without diabetes (3.5 percent per mg/day), although the effect was greater in people with diabetes (interaction P = 0.027). Similarly, increasing ACEI dose was associated with lower mortality in both patients with diabetes (5.9 percent per mg/day) and without diabetes (5.1 percent per mg/day), with similar effect size in the groups (interaction P = 0.76).

"Increasing β-blocker dose is associated with a greater prognostic advantage in CHF patients with diabetes than without diabetes," the authors write.

Two authors disclosed financial ties to the pharmaceutical and medical device industries.

Explore further: Leisure time exercise linked to reduced mortality in T1DM

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Leisure time exercise linked to reduced mortality in T1DM

November 14, 2017
(HealthDay)—For patients with type 1 diabetes, including those with chronic kidney disease (CKD), leisure-time physical activity (LTPA) is associated with reduced risk of all-cause mortality, according to a study published ...

Pay for performance cuts mortality in diabetes patients

October 9, 2017
(HealthDay)—Diabetes disease management through a pay-for-performance (P4P) program cuts diabetes-related, cancer-related, and all-cause mortality, according to a Taiwanese study published online Oct. 5 in the U.S. Centers ...

Incretin tied to better outcomes in NOCS-diabetes

October 29, 2017
(HealthDay)—Incretin treatment appears to improve non-ST-elevation myocardial infarction (NSTEMI) outcomes in patients with type 2 diabetes and non-obstructive coronary artery stenosis (NOCS), according to a study published ...

Antihypertensive ACEIs associated with reduced cardiovascular events, death

March 31, 2014
The blood pressure medication angiotensin-converting enzyme inhibitors (ACEIs) appear to reduce major cardiovascular events and death, as well death from all other causes, in patients with diabetes, while angiotensin II receptor ...

Similar defects ID'd for T2DM, chronic pancreatitis and diabetes

August 2, 2017
(HealthDay)—Patients with type 2 diabetes and those with diabetes secondary to chronic pancreatitis have similarly impaired α-cell responses to oral glucose ingestion and hypoglycemia, according to a study published online ...

Diabetes confers worse prognosis for patients with ACS

July 20, 2016
(HealthDay)—For patients with acute coronary syndromes (ACS), diabetes confers a worse prognosis, according to a study published in the Aug. 1 issue of The American Journal of Cardiology.

Recommended for you

Diagnosing diabetes from a single blood sample

June 18, 2018
Diagnosing type 2 diabetes in clinical practice may require only a single blood sample, according to a study led by researchers at Johns Hopkins Bloomberg School of Public Health.

Lentils significantly reduce blood glucose levels, study reveals

June 13, 2018
Replacing potatoes or rice with pulses can lower your blood glucose levels by more than 20 per cent, according to a first-ever University of Guelph study.

Is there a link between diabetes and Parkinson's disease?

June 13, 2018
People with type 2 diabetes may have an increased risk of having a diagnosis of Parkinson's disease later in life, according to a large study published in the June 13, 2018, online issue of Neurology, the medical journal ...

Double-checking diabetes medications may reduce re-hospitalizations

June 11, 2018
Clinicians may take upwards of 15 minutes to double-check a patient's medication list in an electronic health record system, but according to a new study, this reconciliation process may be well worth the time for diabetes ...

How a gene linked to obesity could provide new insights into diabetes

June 8, 2018
A gene previously linked with obesity has been found to affect how the body processes insulin, with potential implications for some forms of diabetes.

New hope from the 'seven year switch' in type 1 diabetes

June 8, 2018
New research has shown that the rapid decline in insulin production that causes Type 1 diabetes continues to fall over seven years and then stabilises.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.