Intensive BP goals reduce risk of cardiovascular events

Intensive BP goals reduce risk of cardiovascular events
(HealthDay)—Intensive blood pressure lowering may similarly decrease cardiovascular events in both patients with and patients without type 2 diabetes mellitus, according to a study published online Dec. 6 in Diabetes Care.

Tom F. Brouwer, M.D., from the University of Amsterdam, and colleagues assessed the effect of both type 2 diabetes and baseline cardiovascular disease risk on the treatment effect of intensive blood pressure lowering based on data and pooled analysis from two randomized trials (ACCORD-BP [Action to Control Cardiovascular Risk in Diabetes Blood Pressure]and SPRINT [Systolic Blood Pressure Intervention Trial] studies; total of 14,094 patients).

The researchers found that the mean baseline was 139.5 mm Hg for the cohort and just over one-third (33.6 percent) had type 2 diabetes. The hazard ratio for the primary composite end point of unstable angina, myocardial infarction, acute heart failure, stroke, and cardiovascular death was 0.82 (P = 0.0017). There was a nonsignificant interaction between intensive blood pressure lowering and type 2 diabetes (P = 0.13). While the 10-year cardiovascular risk was higher in patients with type 2 diabetes, there was no interaction between the risk and treatment effect (P = 0.84).

"Intensive lowering may have a similar favorable effect and appears to decrease in both patients with and patients without type 2 diabetes mellitus," the authors write.


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Citation: Intensive BP goals reduce risk of cardiovascular events (2017, December 19) retrieved 21 February 2019 from https://medicalxpress.com/news/2017-12-intensive-bp-goals-cardiovascular-events.html
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