Pioglitazone associated with lower blood leptin in diabetes

December 21, 2017

(HealthDay)—Compared to placebo, pioglitazone is associated with significantly lower blood leptin levels in patients with type 2 diabetes, according to a meta-analysis published online Dec. 1 in the Journal of Diabetes Investigation.

Satoshi Ida, from Ise Red Cross Hospital in Japan, and colleagues conducted a meta-analysis of (RCTs) investigating the effects of pioglitazone on blood levels in patients with type 2 diabetes. Ten RCTs met eligibility criteria and were included.

The researchers found that the pioglitazone group had significantly lower blood leptin levels compared to the placebo group (standardized mean difference, −0.58; 95 percent confidence interval, −1.12 to −0.05 percent; P = 0.02). There were no significant leptin differences between the and oral antidiabetic drug groups (standardized mean difference, −0.01; 95 percent confidence interval, −0.2 to 0.19 percent; P = 0.93). The authors noted that relatively few RCTs were included in the study and that there was a high level of statistical heterogeneity, which could have affected the results.

"The present study had many limitations, warranting caution for the interpretation of its results and the extrapolation of the findings to other populations," the authors write. "Considering the limitations, we believe that further studies are necessary."

Explore further: Greater benefit for pioglitazone in high-risk patients post stroke

More information: Abstract
Full Text

Related Stories

Greater benefit for pioglitazone in high-risk patients post stroke

September 19, 2017
(HealthDay)—For patients after an ischemic stroke or transient ischemic attack, pioglitazone is associated with greater benefit for those at higher risk for stroke or myocardial infarction (MI), according to a study published ...

Pioglitazone has limited effect in lipoatrophic diabetes

September 20, 2017
(HealthDay)—Pioglitazone may not be effective for lowering blood glucose levels, although it is associated with slight improvement in liver function, in lipoatrophic diabetes induced by juvenile dermatomyositis, according ...

Pioglitazone cuts diabetes risk after ischemic stroke, TIA

August 5, 2016
(HealthDay)—For insulin-resistant patients with recent ischemic stroke or transient ischemic attack, pioglitazone is associated with reduced risk of diabetes, according to a study published online July 27 in Diabetes Care.

Ipragliflozin beneficial in T2DM complicated by liver disease

August 3, 2017
(HealthDay)—For patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), ipragliflozin exerts beneficial effects on NAFLD and glycemic control, similar to pioglitazone, according to a study published ...

Pioglitazone improves left ventricular diastolic function

September 29, 2017
(HealthDay)—Pioglitazone improves whole-body and myocardial insulin sensitivity, left ventricular (LV) diastolic function, and systolic function in patients with type 2 diabetes, according to a small study published online ...

Probiotics linked to weight loss in obese, overweight

October 29, 2017
(HealthDay)—Short-term probiotics are associated with reductions in body weight, body mass index (BMI), and fat percentage in overweight or obese subjects, according to research published online Oct. 18 in Obesity Reviews.

Recommended for you

Study shows drug effectiveness in reducing glucocorticoid-induced bone loss

April 25, 2018
About one in every 100 people in the world takes glucocorticoids long term to treat immune-mediated diseases. However, glucocorticoids, such as prednisone, have a side effect—they induce the bone loss called osteoporosis, ...

Implantable islet cells come with their own oxygen supply

April 25, 2018
Since the 1960s, researchers have been interested in the possibility of treating type 1 diabetes by transplanting islet cells—the pancreatic cells that are responsible for producing insulin when blood glucose concentration ...

Bariatric surgery successes lead to type 2 diabetes treatment

April 24, 2018
Bariatric surgery has long yielded almost immediate health benefits for patients with type 2 diabetes, and new findings on the reasons for remission may be the key to developing drug alternatives to surgery.

Hacking human 'drug trafficking' network could make diabetes treatments more effective

April 23, 2018
Making tiny changes to existing diabetes treatments can alter how they interact with cells, and potentially make the medicines more effective.

Vitamin D deficiency linked to greater risk of diabetes

April 19, 2018
An epidemiological study conducted by researchers at University of California San Diego School of Medicine and Seoul National University suggests that persons deficient in vitamin D may be at much greater risk of developing ...

One class of drug used to treat type 2 diabetes may not reduce the risk of death when compared with placebo

April 17, 2018
One class of drug used to treat type 2 diabetes may not reduce the risk of death when compared with placebo, suggests new findings.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.