Plasma volume changes may mediate effects of empagliflozin

December 26, 2017

(HealthDay)—The reduction in risk of cardiovascular (CV) death with empagliflozin is most mediated by changes in hematocrit and hemoglobin, according to research published online Dec. 4 in Diabetes Care.

Silvio E. Inzucchi, M.D., from Yale University in New Haven, Conn., and colleagues assessed the effects of potential mediators, identified post hoc, on the risk of CV death with empagliflozin compared with placebo among participants in the EMPA-REG OUTCOME trial involving 7,020 patients with type 2 diabetes and established cardiovascular disease.

The researchers found that changes in hematocrit and hemoglobin from baseline mediated 51.8 and 48.9 percent, respectively, of the effect of empagliflozin on the risk of CV death versus placebo. Uric acid, fasting plasma glucose, and hemoglobin A1c showed smaller mediation effects (maximum, 29.3 percent). When the effects of empagliflozin on hematocrit, fasting glucose, , and urine albumin-to-creatinine ratio were incorporated into a model, the combined changes from baseline provided 85.2 percent mediation of the effect of empagliflozin on CV death, while updated mean analyses provided 94.6 percent mediation.

"In this exploratory analysis from the EMPA-REG OUTCOME trial, changes in markers of plasma volume were the most important mediators of the reduction in risk of CV death with empagliflozin versus placebo," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Boehringer Ingelheim and Eli Lilly and Co., which funded the EMPA-REG OUTCOME trial.

Explore further: Greater drop in hemoglobin A1c with empagliflozin plus metformin

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Greater drop in hemoglobin A1c with empagliflozin plus metformin

August 16, 2016
(HealthDay)—Twenty-four weeks of empagliflozin + metformin correlates with a significantly greater reduction in hemoglobin A1c (HbA1c) compared with once-daily empagliflozin or twice-daily metformin, according to a study ...

ADA: Empagliflozin linked to reduction in T2DM nephropathy

June 15, 2016
(HealthDay)—For patients with type 2 diabetes at high cardiovascular risk, empagliflozin is associated with a reduction in incident or worsening nephropathy, according to a study published online June 14 in the New England ...

Sequential empagliflozin, linagliptin diabetes Tx effective

January 4, 2017
(HealthDay)—After metformin failure, sequential treatment escalation with empagliflozin and linagliptin is an effective diabetes treatment option due to additive effects on postprandial glucose control, according to a study ...

Empagliflozin lowers high blood pressure and blood sugar in diabetics

June 23, 2014
An investigational drug to treat Type 2 diabetes, empagliflozin, lowers blood pressure in patients with Type 2 diabetes and hypertension (high blood pressure), a new study finds. The results were presented Sunday in a late-breaking ...

Pioglitazone cuts diabetes risk after ischemic stroke, TIA

August 5, 2016
(HealthDay)—For insulin-resistant patients with recent ischemic stroke or transient ischemic attack, pioglitazone is associated with reduced risk of diabetes, according to a study published online July 27 in Diabetes Care.

Diabetes drug trial needs to widen participants to understand full impact of drugs

June 14, 2017
More work needs to be done to examine the real world effects of the commonly prescribed diabetes drug empagliflozin, new research in the journal Diabetes Therapy finds.

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Thirty-year study shows women who breastfeed for six months or more reduce their diabetes risk

January 16, 2018
In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.