Experts seek to standardize treatments for childhood rheumatic diseases

January 15, 2018, Wiley

Pediatric rheumatic diseases are a varied group of rare diseases including juvenile forms of arthritis, lupus, fibromyalgia, and other conditions. Currently, there is considerable variability in how patients with these diseases are treated in clinical practice, making it difficult to understand which therapies work best. A new review article in Arthritis & Rheumatology examines recent efforts to address this challenge.

Ideally, randomized placebo-controlled clinical trials are conducted to help determine the best course of action against a , but such trials are difficult to perform in . Consensus plans (CTPs) are a potential alternative. CTPs are standardized strategies that are developed by a consensus among experts and are intended to help reduce treatment variability and allow for comparisons of different therapies. The Childhood Arthritis and Rheumatology Research Alliance (CARRA), the largest pediatric rheumatology research collaborative in North America, is pioneering the use of CTPs to standardize the common treatments for pediatric rheumatic diseases.

In their review, Sarah Ringold, MD, MS, of Seattle Children's Hospital, and her colleagues present the rationale for the CARRA CTP approach, consider its advantages and disadvantages, and introduce related ongoing research.

"Once a diagnosis is made, providers and and their families can choose together the CTP strategy that they believe will work the best for that ," Dr. Ringold explained. "Information on how the patient is doing on that is then collected at regular clinic visits through a registry. At the end of the proposed study duration, researchers can then compare how the patients do between the different CTPs."

Dr. Ringold noted that ongoing large-scale studies are testing this approach in . Results from these studies will provide more information on the feasibility of this and may provide insights on which therapeutic strategies are most likely to be successful for certain . "The CTP will be even more powerful when coupled with biospecimen collection to facilitate translational research aimed at identifying biomarkers of response and non-response, paving the way towards personalized medicine," she said.

Explore further: Standardized treatment plans developed for new-onset JIA

More information: Sarah Ringold et al, The Childhood Arthritis & Rheumatology Research Alliance Consensus Treatment Plans: Towards Comparative Effectiveness in the Pediatric Rheumatic Diseases, Arthritis & Rheumatology (2018). DOI: 10.1002/art.40395

Related Stories

Standardized treatment plans developed for new-onset JIA

July 3, 2012
(HealthDay) -- Four standardized consensus treatment plans (CTPs) have been developed for patients with new-onset systemic juvenile idiopathic arthritis (JIA), according to research published in the July issue of Arthritis ...

Early therapeutic intervention for pre-RA patients significantly reduces risk of RA

June 15, 2017
The results of a meta-analysis presented today at the Annual European Congress of Rheumatology (EULAR) 2017 press conference has demonstrated that early therapeutic intervention in patients with so-called pre-rheumatoid arthritis ...

New medication guidelines for rheumatic disease patients having joint replacement

June 17, 2017
In the first such collaboration of its kind, an expert panel of rheumatologists and orthopedic surgeons has developed guidelines for the perioperative management of anti-rheumatic medication in patients undergoing total hip ...

Recommendations guide physicians in treatment of systemic juvenile arthritis

September 24, 2013
In the U.S., there are nearly 300,000 children with juvenile arthritis and other rheumatic illnesses according to estimates from the American College of Rheumatology (ACR). For pediatric patients with systemic juvenile idiopathic ...

Trial demonstrates benefits of learning sessions for managing rheumatoid arthritis

May 17, 2017
A new study found that group-based quality improvement sessions help rheumatologists care for rheumatoid arthritis patients with the recommended "treat to target" (TTT) approach to care. This approach involves setting a target ...

Recommended for you

Dietary carbohydrates could lead to osteoarthritis, new study finds

August 9, 2018
Do your knees ache? According to new findings from the Oklahoma Medical Research Foundation, your diet could be a culprit.

Joint study raises questions about treatments for arthritis

August 3, 2018
A study examining how molecules are transported into knee-joint tissue could have major implications for understanding and treating arthritis.

Researchers identify new arthritis severity gene

July 26, 2018
A new gene associated with disease severity in models of rheumatoid arthritis has been identified by researchers at the Icahn School of Medicine at Mount Sinai. The discovery could provide a new pathway for treatment and ...

How the brain plays a role in rheumatoid arthritis inflammation

June 18, 2018
In patients with chronic inflammatory conditions, such as rheumatoid arthritis, there has been limited understanding of how this inflammation affects the brain.

New 3-D imaging analysis technique could lead to improved arthritis treatment

June 18, 2018
An algorithm to monitor the joints of patients with arthritis, which could change the way that the severity of the condition is assessed, has been developed by a team of engineers, physicians and radiologists led by the University ...

Joint resolution: A link between Huntington's disease and rheumatoid arthritis

May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.