Kidney injury common after non-kidney transplants in children

January 9, 2018

(HealthDay)—In children who receive a non-kidney solid organ transplant, acute kidney injury (AKI) is common in the first year after surgery and is associated with an increased risk of chronic kidney disease (CKD), according to a study published online Dec. 29 in the American Journal of Transplantation.

C. Williams, from the University of Toronto, and colleagues determined the incidence of AKI and CKD among 303 children who received a heart, lung, liver, or multi-organ transplant at the Hospital for Sick Children between 2002 and 2011.

The researchers assessed AKI in the first year after transplant and found that perioperative AKI (within the first week) occurred in 67 percent of children and that AKI after the first week occurred in 36 percent. The highest incidence occurred among lung and multi-organ recipients. CKD developed in 23 children (8 percent) after a median follow-up of 3.4 years. End-stage renal disease developed in fewer than five , all within 65 days of transplant. There was a significantly greater risk for developing CKD among those with one AKI episode by three months post-transplant, even after adjustment for age, sex, and estimated at transplant (hazard ratio, 2.77).

"AKI is common in the first year post-transplant and associated with significantly greater risk of developing CKD," the authors write. "Close monitoring for kidney disease may allow for earlier implementation of kidney-sparing strategies to decrease risk for progression to CKD."

Explore further: Kidney failure can complicate long-term outcomes in children receiving solid-organ transplants

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Kidney failure can complicate long-term outcomes in children receiving solid-organ transplants

October 14, 2013
Children who undergo transplants of solid organs have a high risk of developing advanced kidney disease, according to a new national study. Among these children, the highest risk is in those receiving lung or intestinal transplants, ...

Increased cancer risk for childhood kidney recipients

April 5, 2017
(HealthDay)—Childhood kidney recipients have increased cancer risk, according to a study published online March 29 in the American Journal of Transplantation.

In Norway, risk of SCC after organ transplant has fallen

October 20, 2017
(HealthDay)—For organ recipients in Norway, the risk of skin cancer, particularly squamous cell carcinoma (SCC), has decreased since the mid-1980s, according to a study published online Oct. 18 in JAMA Dermatology.

Study suggests need for renal protective care in pediatric lung transplant patients

May 17, 2015
Caucasian and Hispanic children who undergo lung transplantation appear to be at greater risk for developing chronic kidney disease, or CKD, according to a small retrospective study conducted at Texas Children's Hospital.

Long-term benefits to the liver-kidney transplant

April 15, 2016
A new study from physicians at Mayo Clinic in Rochester, found there may be long-term benefits to simultaneous liver-kidney transplantation versus kidney transplantation alone. The study, "Decreased Chronic Cellular and Antibody-Mediated ...

Research highlights impact of kidney injury on non-renal solid organ transplants

July 27, 2017
Research led by a University of Cincinnati (UC) scientist shows the impact of acute kidney injury requiring dialysis (AKI-D) on patients receiving non-renal solid organ transplantation (NRSOT), including cardiac and liver ...

Recommended for you

Study ends debate over role of steroids in treating septic shock

January 19, 2018
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year.

New approach could help curtail hospitalizations due to influenza infection

January 18, 2018
More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014-15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help ...

Flu may be spread just by breathing, new study shows; coughing and sneezing not required

January 18, 2018
It is easier to spread the influenza virus (flu) than previously thought, according to a new University of Maryland-led study released today. People commonly believe that they can catch the flu by exposure to droplets from ...

Zika virus damages placenta, which may explain malformed babies

January 18, 2018
Though the Zika virus is widely known for a recent outbreak that caused children to be born with microencephaly, or having a small head, and other malformations, scientists have struggled to explain how the virus affects ...

Certain flu virus mutations may compensate for fitness costs of other mutations

January 18, 2018
Seasonal flu viruses continually undergo mutations that help them evade the human immune system, but some of these mutations can reduce a virus's potency. According to new research published in PLOS Pathogens, certain mutations ...

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.