Higher biopsy rates for women undergoing screening breast MRI

February 14, 2018

(HealthDay)—Women undergoing screening breast magnetic resonance imaging (MRI) have higher biopsy rates and significantly lower cancer yield findings compared with screening mammography alone, regardless of personal history of breast cancer (PHBC), according to a study published online Feb. 12 in JAMA Internal Medicine.

Diana S.M. Buist, Ph.D., M.P.H., from the Kaiser Permanente Washington Health Research Institute in Seattle, and colleagues conducted an observational cohort study of six Breast Cancer Surveillance Consortium registries. Data were included for a sample of 812,164 women undergoing a total of 2,048,994 digital and/or breast MRI screening episodes from 2003 through 2013. Outcomes were stratified by PHBC.

The researchers found that for women with PHBC, age-adjusted core and surgical biopsy rates were doubled after MRI versus mammography (57.1 versus 23.6 per 1,000 episodes). The differences were even larger for women without PHBC (84.7 and 14.9 per 1,000 episodes, respectively). In women with PHBC, the ductal carcinoma in situ and invasive biopsy yield was significantly higher after mammography versus MRI episodes (404.6 versus 267.6 per 1,000 episodes); for women without PHBC, the yield was nonsignificantly higher (279.3 versus 214.6 per 1,000 episodes). Regardless of PHBC, high-risk benign lesions were more commonly identified after MRI.

"Further work is needed to identify who will benefit from screening MRI to ensure an acceptable benefit-to-harm ratio," the authors write.

Explore further: Including diagnosis related costs, 3-D mammography costs less than digital mammography

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Including diagnosis related costs, 3-D mammography costs less than digital mammography

December 8, 2017
Although digital breast tomosynthesis (DBT), or 3-D mammography, costs more than a digital mammography (DM) screening, it actually may help rein in cancer screening costs, according to preliminary findings (PD7-05) presented ...

False-positive mammography results are common

January 12, 2016
(HealthDay)—For women undergoing digital mammography screening, false-positive results are common, especially among younger women and those with risk factors, according to research published online Jan. 12 in the Annals ...

Community practices not following guidelines for MRI breast cancer screening

December 7, 2017
Guidelines are not being followed to ensure that breast cancer screening of high risk women, such as those with a strong family history of breast cancer, includes an additional MRI (magnetic resonance imaging) scan. According ...

Women prefer getting mammograms every year

November 21, 2017
Women prefer to get their mammograms every year, instead of every two years, according to a new study being presented next week at the annual meeting of the Radiological Society of North America (RSNA).

Does MRI plus mammography improve detection of new breast cancer after breast conservation therapy?

June 22, 2017
A new article published by JAMA Oncology compares outcomes for combined mammography and MRI or ultrasonography screenings for new breast cancers in women who have previously undergone breast conservation surgery and radiotherapy ...

Recommended for you

PARP inhibitor improves progression-free survival in patients with advanced breast cancers

August 15, 2018
In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over ...

Scientists discover chemical which can kill glioblastoma cells

August 15, 2018
Aggressive brain tumour cells taken from patients self-destructed after being exposed to a chemical in laboratory tests, researchers have shown.

New clues into how 'trash bag of the cell' traps and seals off waste

August 15, 2018
The mechanics behind how an important process within the cell traps material before recycling it has puzzled scientists for years. But Penn State researchers have gained new insight into how this process seals off waste, ...

Three scientists share $500,000 prize for work on cancer therapy

August 15, 2018
Tumors once considered untreatable have disappeared and people previously given months to live are surviving for decades thanks to new therapies emerging from the work of three scientists chosen to receive a $500,000 medical ...

RUNX proteins act as regulators in DNA repair, study finds

August 15, 2018
A study by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed that RUNX proteins are integral to efficient DNA repair via the Fanconi Anemia (FA) ...

Chemicals found in vegetables prevent colon cancer in mice

August 14, 2018
Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study from the Francis Crick Institute shows.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.