A new mechanism involved in Staphylococcus aureus virulence and antibiotic resistance

Staphylococcus aureus: A new mechanism involved in virulence and antibiotic resistance
Staphylococcus aureus cells ('golden staph') observed by scanning electron microscopy Credit: Institut Pasteur/Mélanie Falord and Tarek Msadek -- Colorization by Jean-Marc Panaud

An Institut Pasteur-CNRS research team has characterized a Staphylococcus aureus gene involved in virulence, biofilm formation and resistance to certain antibiotics. These results open up new avenues for understanding the control of S. aureus virulence mechanisms. This work was recently published in the journal PLoS Pathogens.

Staphylococcus aureus is part of the natural skin flora, preferentially colonizing external mucosa in 30 to 50 percent of the population, healthy carriers who develop no symptoms. But it is also a major human pathogen, causing diseases ranging from skin lesions (boils, impetigo, etc.) to endocarditis, acute pneumonia, osteomyelitis or sepsis. It is the leading Gram-positive bacterium responsible for hospital-acquired infections. The most dangerous strains are those that display resistance to multiple antibiotics. Such is the case of methicillin-resistant MRSA, widespread in hospitals and posing a major public health concern.

A team led by Tarek Msadek, a researcher at the Institut Pasteur (CNRS ERL 3526), is studying bacterial responses to environmental variations and their role in Staphylococcus aureus pathogenesis and host interactions. These responses are often genetically controlled by so-called "two-component" systems. During the study of one such system called WalKR, which is essential for bacterial survival, they characterized an additional component, SpdC, a membrane protein whose role was unknown. This component interacts with the WalKR system to control its activity, and its absence leads to a strong decrease in virulence, (bacterial aggregates), and resistance to certain antibiotics.

These results suggest that inhibition of SpdC could be used as an approach to combat S. aureus infections and understand the mechanisms involved in its transition from commensal to pathogen.


Explore further

Researcher exposes MRSA risk at northeast Ohio beaches

More information: Olivier Poupel et al, SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus, PLOS Pathogens (2018). DOI: 10.1371/journal.ppat.1006917
Journal information: PLoS Pathogens

Provided by Pasteur Institute
Citation: A new mechanism involved in Staphylococcus aureus virulence and antibiotic resistance (2018, March 26) retrieved 15 October 2019 from https://medicalxpress.com/news/2018-03-mechanism-involved-staphylococcus-aureus-virulence.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
5 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more