Montreal Parkinson risk of dementia scale deemed accurate

March 30, 2018

(HealthDay)—The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia, according to a study published online March 26 in JAMA Neurology.

Benjamin K. Dawson, from McGill University in Montreal, and colleagues conducted a multicenter study using four diverse Parkinson's disease cohorts with a prospective 4.4-year follow-up to examine the predictive validity of the Montreal Parkinson Risk of Dementia Scale. A total of 717 patients with Parkinson's disease were recruited; 607 were -free at baseline and followed for one year or more.

The researchers found that all eight items of the Montreal Parkinson Risk of Dementia Scale independently predicted the development of dementia (significant at the 5 percent level). In the high-risk group ( >5) the annual conversion rate to dementia was 14.9 percent, compared with 5.8 and 0.6 percent in the intermediate- (score, 4 to 5) and low-risk (score, 0 to 3) groups. Across all cohorts, the overall predictive validity by the area under the receiver operator characteristic curve was 0.877. Sensitivity was 77.1 percent and specificity 87.2 percent for a cut-off of 4 or greater, with positive and negative predictive values of 43.9 and 96.7 percent, respectively; positive and negative likelihood ratios were 5.94 and 0.26, respectively. There were correlations for results with makers of Alzheimer's pathology and neuropsychological test results.

"Future studies using head-to-head comparisons or refinement of weighting would be of interest," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Explore further: Altered brain communication could be predictive marker of dementia in Parkinson's disease

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Altered brain communication could be predictive marker of dementia in Parkinson's disease

March 30, 2016
Dementia will develop in about 80% of patients with Parkinson's disease, and a new study has found significant variability in brain signaling that could serve as a predictive marker for identifying which patients are at highest ...

DBS safe but not beneficial in parkinson's dementia

December 19, 2017
(HealthDay)—Low-frequency deep brain stimulation of the nucleus basalis of Meynert (NBM DBS) can be safely conducted in patients with Parkinson's disease dementia, but it does not result in significant improvements in primary ...

Physically fit women nearly 90 percent less likely to develop dementia

March 14, 2018
Women with high physical fitness at middle age were nearly 90 percent less likely to develop dementia decades later, compared to women who were moderately fit, according to a study published the March 14, 2018, online issue ...

What is survival among patients with Parkinson, Dementia with lewy bodies?

May 15, 2017
A new article published by JAMA Neurology compares survival rates among patients with synucleinopathies, including Parkinson disease, dementia with Lewy bodies, Parkinson disease dementia and multiple system atrophy with ...

TBI is associated with increased dementia risk for decades after injury

January 30, 2018
Traumatic brain injuries increase the risk of a dementia diagnosis for more than 30 years after a trauma, though the risk of dementia decreases over time, according to a new study published this week in PLOS Medicine by Anna ...

Drug may help those with dementia with Lewy bodies

January 24, 2018
New help may be on the way for people with dementia with Lewy bodies, which is the second most common neurodegenerative type of dementia after Alzheimer's disease. The disease can cause movement problems and issues such as ...

Recommended for you

Pregnancy history may be tied to Alzheimer's disease

July 18, 2018
A woman's history of pregnancy may affect her risk of Alzheimer's disease decades later, according to a study published in the July 18, 2018, online issue of Neurology, the medical journal of the American Academy of Neurology. ...

Molecular tracer, seen with PET scan, shows concentrations of abnormal proteins

July 17, 2018
In a small study of military personnel who had suffered head trauma and had reported memory and mood problems, UCLA researchers found brain changes similar to those seen in retired football players with suspected chronic ...

Yale-developed test for Alzheimer's disease directly measures synaptic loss

July 16, 2018
Yale researchers have tested a new method for directly measuring synaptic loss in individuals with Alzheimer's disease. The method, which uses PET imaging technology to scan for a specific protein in the brain linked to synapses, ...

New study highlights Alzheimer's herpes link, experts say

July 12, 2018
A new commentary by scientists at the Universities of Manchester and Edinburgh on a study by Taiwanese epidemiologists supports the viability of a potential way to reduce the risk of Alzheimer's disease.

Practice imperfect—repeated cognitive testing can obscure early signs of dementia

July 12, 2018
Alzheimer's disease (AD) is a progressive, neurodegenerative condition that often begins with mild cognitive impairment or MCI, making early and repeated assessments of cognitive change crucial to diagnosis and treatment.

The 'Big Bang' of Alzheimer's: Scientists ID genesis of disease, focus efforts on shape-shifting tau

July 10, 2018
Scientists have discovered a "Big Bang" of Alzheimer's disease – the precise point at which a healthy protein becomes toxic but has not yet formed deadly tangles in the brain.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.