Neural markers of depression resilience ID'd in female teens

Neural markers of depression resilience ID'd in female teens
(HealthDay)—Adolescent females at high familial risk of depression who do not go on to develop depression have compensatory functional connectivity patterns in emotion regulatory networks, according to a study published online March 21 in JAMA Psychiatry.

Adina S. Fischer, M.D., Ph.D., from Stanford University in California, and colleagues examined neural functional connectivity correlates of resilience in 65 at high and low familial risk for . Twenty were at high risk and did not develop depression (resilient), 20 were at high risk and did develop depression (converted), and 25 were at low risk with no history of psychopathology (control).

The researchers found that compared with converted adolescent females, those in the resilient group had greater connectivity between the amygdala and orbitofrontal cortex and between the and frontotemporal regions. In the resilient group only, there was a correlation for strength of amygdala-orbitofrontal cortex connectivity with positive life events. Greater connectivity was seen within frontal and limbic networks for resilient females versus controls. Greater salience network connectivity was seen for both high-risk groups: the converted group had greater intranetwork connectivity than the resilient and control groups; the resilient group had greater salience network connectivity with the superior frontal gyrus than the converted group.

"Further studies are warranted concerning connectivity-associated targets for promoting resilience in high-risk individuals," the authors write.

Explore further

New links between genetic abnormality and brain function in Huntington's disease

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Journal information: JAMA Psychiatry

Copyright © 2018 HealthDay. All rights reserved.

Citation: Neural markers of depression resilience ID'd in female teens (2018, March 23) retrieved 26 June 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more