Caffeine therapy for apnea of prematurity safe over long term

Caffeine therapy for apnea of prematurity safe over long term

(HealthDay)—Neonatal caffeine therapy for apnea of prematurity has no detrimental long-term effects and even improves some neurologic measures, according to a study published online April 11 in Pediatrics.

Ines M. Mrner-Lavanchy, Ph.D., from Monash University in Australia, and colleagues investigated the effects of neonatal caffeine therapy in very (500 to 1,250 g) infants by measuring neurobehavioral outcomes as part of an 11-year follow-up. General intelligence, attention, executive function, visuomotor integration and perception, and behavior were measured in up to 870 children. Regression models were used to evaluate the effects of caffeine therapy.

The researchers found that neurobehavioral outcomes were generally similar for both the caffeine and placebo group. Compared to the , the caffeine group performed better in fine motor coordination (P = 0.01), visuomotor integration (P < 0.05), visual perception (P = 0.02), and visuospatial organization (P = 0.003).

"General intelligence, attention, and behavior were not adversely affected by caffeine, which highlights the long-term safety of therapy for apnea of prematurity in very low birth weight neonates," the authors write.

More information: Abstract/Full Text (subscription or payment may be required)

Journal information: Pediatrics

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Citation: Caffeine therapy for apnea of prematurity safe over long term (2018, April 11) retrieved 3 March 2024 from
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