DPP-4I not tied to increased risk of acute pancreatitis in seniors

DPP-4I not tied to increased risk of acute pancreatitis in seniors

(HealthDay)—For older adults, dipeptidyl peptidase 4 inhibitors (DPP-4Is) are not associated with increased risk of acute pancreatitis, according to a study published online April 4 in Diabetes Care.

Jin-Liern Hong, Ph.D., from the University of North Carolina at Chapel Hill, and colleagues examined the risks of among U.S. Medicare beneficiaries, aged 66+ years, initiating DDP-4Is versus thiazolidinediones or sulfonylureas. Participants had no history of pancreatic disease or alcohol-related diseases.

The researchers found that the risk of acute pancreatitis was not increased comparing 49,374 DPP-4I initiators with 132,223 sulfonylurea initiators (weighted hazard ratio, 1.01; 95 percent confidence interval, 0.83 to 1.24) and comparing 57,301 DPP-4I initiators with 32,612 thiazolidinedione initiators (weighted hazard ratio, 1.11; 95 percent confidence interval, 0.76 to 1.62). The association was not modified by age and sex. Acute pancreatitis incidence was increased for DDP-4I and sulfonylurea initiators but not for thiazolidinedione initiators (2.3 and 2.4 versus 1.5 per 1,000 person-years, respectively), among patients with cardiovascular disease (CVD). The risk of acute pancreatitis was increased among patients with CVD taking DPP-4Is versus thiazolidinediones (weighted hazard ratio, 1.84; 95 percent confidence interval, 1.02 to 3.35), but not compared to sulfonylureas.

"Our study provides evidence that DPP-4I is not associated with an increased risk of acute pancreatitis in overall," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.


Explore further

DPP-4i treatment doesn't up MI, stroke risk in seniors

More information: Abstract/Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2018 HealthDay. All rights reserved.

Citation: DPP-4I not tied to increased risk of acute pancreatitis in seniors (2018, April 10) retrieved 18 July 2019 from https://medicalxpress.com/news/2018-04-dpp-4i-tied-acute-pancreatitis-seniors.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
3 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more