Lung diseases share molecular signature

April 6, 2018, Vanderbilt University

The fibrotic lung diseases BPD (bronchopulmonary dysplasia) and IPF (idiopathic pulmonary fibrosis) affect preterm infants and older adults, respectively. Evidence suggests that these diseases involve dysregulation of lung repair processes, including Wnt signaling.

Jennifer Sucre, MD, and colleagues previously showed that a certain modification (phosphorylation) of the protein beta-catenin—part of the Wnt signaling pathway—was associated with fibrotic changes in BPD.

Now, using a library of normal and diseased human lung samples, they have demonstrated that two forms of phosphorylated beta-catenin have the same cellular pattern in early normal lung development and in BPD and IPF. The signature was associated with increased expression of a Wnt target gene.

The findings, reported in the April issue of the American Journal of Pathology, support the concept that repair of involves activation of signaling pathways that are important during development. They also suggest that targeting beta-catenin phosphorylation may be useful for the treatment and prevention of both BPD and IPF.

Explore further: Cigarette smoke curbs lung's self-healing

More information: Jennifer M.S. Sucre et al. A Shared Pattern of β-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis, The American Journal of Pathology (2018). DOI: 10.1016/j.ajpath.2017.12.004

Related Stories

Cigarette smoke curbs lung's self-healing

March 2, 2017
Smoke from cigarettes blocks self-healing processes in the lungs and consequently can lead to chronic obstructive pulmonary disease (COPD). Researchers at the Helmholtz Zentrum München, partner in the German Center for Lung ...

New method enables improved drug target validation for COPD treatment

April 30, 2015
Scientists at Helmholtz Zentrum München have succeeded in testing the effectiveness of new approaches for treating chronic obstructive pulmonary disease (COPD) on ex vivo 3D human lung tissue cultures (3D-LTCs). The results ...

Lithium and bone healing

July 30, 2007
Researchers have described a novel molecular pathway that may have a critical role in bone healing and have suggested that lithium, which affects this pathway, has the potential to improve fracture healing.

COPD – what causes the lungs to lose their ability to heal?

December 16, 2016
In chronic obstructive pulmonary disease (COPD), the patients' lungs lose their ability to repair damages on their own. Scientists at the Helmholtz Zentrum München, partner in the German Center for Lung Research (DZL) now ...

Progression of lung fibrosis blocked in mouse model

October 5, 2011
A study by researchers at the University of California, San Diego School of Medicine may lead to a way to prevent the progression, or induce the regression, of lung injury that results from use of the anti-cancer chemotherapy ...

Restoring lipid synthesis could reduce lung fibrosis

March 6, 2018
Pulmonary fibrosis, an ongoing process of scarring that leaves patients chronically short of breath, can progress in severity until the only course of treatment is lung transplant. A new study shows that restoring the lipids ...

Recommended for you

Fetal gene therapy prevents fatal neurodegenerative disease

July 16, 2018
A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new study led by UCL, the KK Women's and Children's Hospital and National University Health System ...

New study finds that fat consumption is the only cause of weight gain

July 13, 2018
Scientists from the University of Aberdeen and the Chinese Academy of Sciences have undertaken the largest study of its kind looking at what components of diet—fat, carbohydrates or protein—caused mice to gain weight.

Basic research in fruit flies leads to potential drug for diseases afflicting millions

July 13, 2018
River blindness and elephantiasis are debilitating diseases caused by parasitic worms that infect as many as 150 million people worldwide. They are among the "neglected tropical diseases" for which better treatments are desperately ...

Light based cochlear implant restores hearing in gerbils

July 12, 2018
A team of researchers with members from a variety of institutions across Germany has developed a new type of cochlear implant—one based on light. In their paper published in the journal Science Translational Medicine, the ...

Researchers discover gene that controls bone-to-fat ratio in bone marrow

July 12, 2018
In an unexpected discovery, UCLA researchers have found that a gene previously known to control human metabolism also controls the equilibrium of bone and fat in bone marrow as well as how an adult stem cell expresses its ...

Intensive care patients' muscles unable to use fats for energy

July 12, 2018
The muscles of people in intensive care are less able to use fats for energy, contributing to extensive loss of muscle mass, finds a new study co-led by UCL, King's College London and Guy's and St Thomas' NHS Foundation Trust.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.