Increased nerve activity may raise blood pressure in anxiety

blood pressure
Credit: CC0 Public Domain

Sympathetic nerve activity to skeletal muscle blood vessels—a function of the nervous system that helps regulate blood pressure—increases during physiological and mental stress in people with chronic anxiety, a new study finds. Over time, this response may increase the risk of high blood pressure and heart disease, although the study did not test this specifically. The study, published ahead of print in the Journal of Neurophysiology, was chosen as an APSselect article for May.

Researchers from the University of Iowa studied the responses of two groups of volunteers after they experienced physiological and mental stressors. One group of people had as determined by standardized scales used to measure anxiety and depression. The did not have anxiety. The research team placed the volunteers' hands in an ice-water bath for two minutes to assess their responses to physiological stress. After a brief recovery period, the participants verbally solved simple math problems as fast as they could for four minutes to induce . Before the start of each test, the researchers gave the participants a two-minute "warning" countdown.

The research team inserted a tiny microelectrode into a nerve near the back of the participants' knee to measure throughout testing. They monitored the volunteers' rate of blood flow and blood pressure in the upper arm and heart rate via a finger cuff during both activities. Blood samples showed that the anxiety group had higher levels of norepinephrine, a hormone that sympathetic nerve fibers release in response to stress, before testing began. Norepinephrine causes the blood vessels to contract, which raises .

The researchers observed increased nerve responses in both groups before and during the ice bath and math activities. However, the increase "was significantly greater among [the anxiety group] compared with [the control group], suggesting an enhanced sympathetic anticipatory response," the research team wrote.

Heart rate increased during the two-minute countdown, another sign that the anticipation of impending stress or discomfort caused physiological changes in the body. However, there was no significant difference between the anxiety and control groups. "Future studies are warranted to determine whether augmented [sympathetic nerve activity] is associated with deleterious end-organ consequences in persons with anxiety and cardiovascular disease or cardiovascular disease risk factors," the researchers wrote.

More information: Seth W. Holwerda et al, Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety, Journal of Neurophysiology (2018). DOI: 10.1152/jn.00064.2018

Journal information: Journal of Neurophysiology
Citation: Increased nerve activity may raise blood pressure in anxiety (2018, May 3) retrieved 23 February 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Meditation can soothe the anxious soul in just one session


Feedback to editors