Punctal plug deemed beneficial in ocular surface disease

May 4, 2018

(HealthDay)—For patients with ocular surface disease (OSD) using prostaglandin analogue monotherapy, a punctal plug improves OSD and reduces intraocular pressure (IOP), according to a study published online April 26 in Clinical & Experimental Ophthalmology.

Justin C. Sherwin, M.B., B.S., from the University of Oxford in the United Kingdom, and colleagues conducted a randomized controlled trial to examine whether a punctal improves OSD and reduces IOP in patients using prostaglandin analogue monotherapy. Out of 60 eligible subjects with symptomatic OSD from glaucoma clinics, 48 participated. One eye received an inferior punctal plug, so the fellow eye was considered a control. At baseline and after six weeks, ocular surface index, tear-film breakup time, Oxford Cornea Score, tear osmolarity, and IOP were compared.

The researchers found that following plug insertion there was a reduction in OSD index (mean difference [MD], 14.5). In eyes receiving plugs, the tear-film breakup time increased compared with control eyes (MD, 2.3 seconds), while there was a decrease in the Oxford Cornea Score (MD, 0.5) and tear osmolarity (MD, 10 mOsm/L). IOP was lowered significantly with punctal plugs (MD, 1.5 mm Hg). Efficacy was similar regardless of prostaglandin preservative status or lubricant drop use in subgroup analyses. Extrusion occurred in 8.5 percent, and epiphora increased in 6.5 percent of eyes, although plugs were well tolerated.

"Punctal plug insertion improves subjective and objective measures of OSD and results in a reduced IOP in patients with symptomatic ocular surface disease using analogue monotherapy," the authors write.

Explore further: Omega-3 essential fatty acids may protect corneal nerves in dry eye

More information: Abstract/Full Text (subscription or payment may be required)

Related Stories

Omega-3 essential fatty acids may protect corneal nerves in dry eye

March 21, 2017
(HealthDay)—Oral, long-chain omega-3 (ω-3) essential fatty acid (EFA) supplementation is neuroprotective to corneal nerves for patients with dry eye disease, according to a study published online March 12 in Ophthalmic ...

Tear duct implant effective at reducing pain and inflammation in cataract surgery patients

October 19, 2014
The first tear duct implant developed to treat inflammation and pain following cataract surgery has been shown to be a reliable alternative to medicated eye drops, which are the current standard of care, according to a study ...

Open-angle glaucoma: Poor data for the fixed combination tafluprost/timolol

April 7, 2015
The fixed combination of the drugs tafluprost and timolol (trade name: Taptiqom) has been approved in Germany since December 2014 for adults with open-angle glaucoma or increased intraocular pressure (ocular hypertension). ...

Prostaglandin analogs impact circadian IOP-related patterns

December 9, 2015
(HealthDay)—For patients with glaucoma, prostaglandin analogs seem to affect circadian intraocular pressure (IOP)-related patterns, according to a study published in the December issue of Clinical & Experimental Ophthalmology.

Combo Tx superior for polypoidal choroidal vasculopathy

October 9, 2017
(HealthDay)—Combination therapy consisting of ranibizumab plus verteporfin photodynamic therapy (vPDT) is superior to ranibizumab monotherapy for treatment of eyes with polypoidal choroidal vasculopathy (PCV), according ...

Low vitamin D tied to dry eye syndromes

August 23, 2015
(HealthDay)—Patients with vitamin D deficiency should be evaluated for dry eye syndromes, according to a study published online Aug. 13 in the International Journal of Rheumatic Diseases.

Recommended for you

Researchers reverse congenital blindness in mice

August 15, 2018
Researchers funded by the National Eye Institute (NEI) have reversed congenital blindness in mice by changing supportive cells in the retina called Müller glia into rod photoreceptors. The findings advance efforts toward ...

Autoimmune response drives vision loss in glaucoma

August 10, 2018
A research team from Massachusetts Eye and Ear and the Massachusetts Institute of Technology has shown that immune cells in the eye that developed in response to early exposure to bacteria are a key contributor to progressive ...

Is too much screen time harming children's vision?

August 6, 2018
As children spend more time tethered to screens, there is increasing concern about potential harm to their visual development. Ophthalmologists—physicians who specialize in medical and surgical eye care—are seeing a marked ...

Researchers chart a course for AI-aided diagnosis of degenerative eye conditions

August 1, 2018
A team of researchers from Johns Hopkins is leading the way in understanding how the advent of electronic medical records with large image databases and advances in artificial intelligence with deep learning can offer medical ...

Derivative of turmeric eye drops could treat glaucoma

July 24, 2018
A derivative of turmeric could be used in eye drops to treat the early stages of glaucoma, finds a new study led by UCL and Imperial College London researchers.

Researchers are one step closer to developing eye drops to treat age-related macular degeneration

July 19, 2018
Scientists at the University of Birmingham are one step closer to developing an eye drop that could revolutionise treatment for age-related macular degeneration (AMD).

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.