Could switching blood pressure medication timing extend your life?

Could switching blood pressure medication timing extend your life?
The BedMed study, led by a U of A researcher, will look at the purported health benefits—and potential risks—of having patients take blood pressure medication at bedtime instead of daytime. Credit: University of Alberta

More than seven years ago, a big health finding reported on in a peer-reviewed journal went largely unnoticed.

"Spanish chronobiologists found that taking your at bedtime instead of in the morning reduced the risk of heart attack, stroke and death by 61 per cent," said Scott Garrison, an associate professor in the University of Alberta's Faculty of Medicine & Dentistry.

"If this were true, it would extend people's life expectancy by 5.5 years. The next best thing we have for lowering heart attack and stroke risk is cholesterol-lowering medication, and that's only a 35 per cent reduction."

One of the reasons the extraordinary finding went largely unnoticed is because "extraordinary claims require extraordinary evidence to be believed," said Garrison.

His team of researchers is embarking on a massive study in Western Canada that will finally answer the question: when is the best time to take blood medication?

The study, called BedMed—which has already recruited 947 patients (and counting) with the help of 155 family physicians—is not only investigating the purported health benefits, but also the risks.

"We do not recommend that the public change when they take any medication without consulting with their doctor," said Garrison, who is leading the study.

"There is the possibility of huge benefits from changing the time you take your blood pressure medicine, but there could also be unrecognized harms no one has looked at before."

Why timing may matter

For the one in five Canadians with high blood pressure, medication is often prescribed for daytime use based on the assumption that the medication will combat the increase in blood pressure that may happen while the person is active, explained Garrison.

"The normal pattern is for blood pressure to be higher during the day and lower at night," he added.

So why might taking blood pressure medication at night, when blood pressure is already lower, reduce the risk of a heart attack?

"We know that if you don't dip lower at night, you have a higher risk of having a heart attack or stroke," said Garrison. "Taking the medication at night preferentially lowers bedtime blood pressure and creates a more normal rhythm. If the benefit to bedtime prescribing is real, that may be why."

Garrison added that BedMed aims to show whether there truly is a benefit for everyone. Their goal is to recruit 8,750 participants from Alberta, British Columbia and Manitoba.

"This is a pragmatic trial. We are trying to answer the question for everyone, regardless of how complex their health issues might be. "

The potential risks

In addition to investigating whether taking blood pressure medication at night time reduces the risk of heart attacks, strokes and death, Garrison said BedMed will attempt to find three potential harms.

Visual changes

"It has been shown that if you have glaucoma, and if you also have lower than normal blood pressure while you sleep, your vision deteriorates more quickly. For this reason, we're excluding anyone with known glaucoma and watching closely for this outcome."

Falls and fractures

There is a legitimate concern that older adults who get up in the middle of the night may experience dizziness—due to lower than usual blood pressure—and fall and cause a fracture. "Our aim is to ascertain the true risk of this occurring when blood pressure medication is taken at nighttime."

Dementia

"This concern is pure speculation. Lowering overnight blood pressure could be helpful or harmful so far as developing dementia," added Garrison. He added that the relationship between pressure and dementia is highly complex.

Unique approach

BedMed is the only study of its kind in North America to be primary care-led. The pilot work for this project involved 236 family physicians participating in 54 Western Canadian communities—thanks to the Pragmatic Trials Collaborative, a unique model of study design developed by Garrison, which does not impede physician work flow or require a major time commitment.

"We're hoping to get the participation of around 500 physicians," said Garrison, who pointed out how the participation of family physicians is critical to accessing patients for all kinds of research. Their participation entails sending out a letter to suitable patients informing them of BedMed and managing any resulting medication changes.

The study is also unique because it has been co-developed and co-managed with a 10-member patient working group, noted Garrison.

"The insights and values of our patient partners played a critical role in the study development, including which risks and benefits we're searching for," he added.

How to participate in the study

Anyone who is on and lives in Alberta, British Columbia or Manitoba may apply online or call 1-844-492-7570 to see whether they're eligible to participate in BedMed.

"We screen participants and start the process off with a phone call. We're keen to hear from anyone who's interested in taking part," said Garrison.

Participants will need to supply a list of medications, and will be screened for cognition and past health issues. If patients are randomized into a group that is changing medication timing, they might need to visit their family physician to guide and monitor the switch.

Participants will be in the study for about three years, but the only commitment after the switch is a phone interview or email survey every six months.


Explore further

New guidelines mean 1 in 3 adults may need blood pressure meds

Provided by University of Alberta
Citation: Could switching blood pressure medication timing extend your life? (2018, June 20) retrieved 20 January 2019 from https://medicalxpress.com/news/2018-06-blood-pressure-medication-life.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
211 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more