Biomarker discovered for most common form of heart failure

Biomarker discovered for most common form of heart failure
Heart cells as seen through a microscope. Credit: Cedars-Sinai

A team led by a Cedars-Sinai physician-scientist has discovered a biomarker—a protein found in the blood—for the most common type of heart failure, a new study published today in JAMA Cardiology shows.

Heart failure with preserved ejection fraction (HFpEF) affects more than 6.5 million Americans each year. And now, thanks to the discovery of the first-ever biomarker for HFpEF, a simple test can reveal whether a patient's is not making enough of an important protein. If the protein levels are decreased, the biomarker signal increases and physicians will be able to diagnose sooner, prescribe corrective medicines and prevent further disease progression.

"By the time heart failure symptoms develop, the critical window for corrective therapy has typically closed," said Robin Shaw, MD, Ph.D., the Wasserman Endowed Chair in Cardiology and professor of Medicine at the Smidt Heart Institute at Cedars-Sinai and principal investigator on the study. "Our discovery allows us to not only diagnose the disease sooner, but also to treat patients before that critical period of early intervention for lifesaving care has closed."

Heart failure with preserved ejection fraction is a condition where the heart can contract, but has problems relaxing—limiting the heart's ability to fill with blood between each beat—and therefore lowers the amount of blood moving forward with each contraction. Prior to the discovery of the biomarker, clinicians had to wait for patients to have symptoms to make a diagnosis of HFpEF and had to use an echocardiogram that measured how well the heart relaxed. There was no method to gauge the health of the heart muscle before symptoms developed or determine the severity of disease once symptoms were present.

The biomarker—named cBIN1 Score, or CS for short—allows doctors to measure muscle deterioration and measure a protein that regulates the heart's ability to both contract and relax. As the protein decreases, CS increases, serving as an indication of onset heart failure. The CS biomarker can be measured using a simple blood draw.

The CS biomarker is designed to be used in an outpatient clinic setting. For patients with known HFpEF, doctors can draw a CS level and use it to both guide current care, including medication adjustments, and predict the chances of a patient being admitted to the hospital in the next 12 months.

"More broadly, this discovery will allow the most at-risk patients—including older patients and patients with , diabetes or dyslipidemia—to be checked during an annual exam from their primary care physician," said Eduardo Marbán, MD, Ph.D., director of the Smidt Heart Institute. "This pivotal research has the potential to impact millions of people and serve as a critical tool for preventive heart care."

Symptoms of heart failure typically appear as fatigue, fluid weight gain, leg swelling and shortness of breath. Heart with preserved is typically diagnosed in elderly people or those living with high blood pressure, diabetes, elevated cholesterol, hypertension, obesity, obstructive sleep apnea, anemia, iron deficiency or diabetes. Its prevalence is projected to rise drastically over the coming decades. Previous studies have shown that women represent the majority of diagnosed with the disease.

As next steps, Cedars-Sinai researchers plan on identifying specialty populations in which the CS could be useful, including sex-based differences, those who have undergone a heart transplant or valve replacement, as well as individuals with no known heart disease or risk factors.


Explore further

Microvascular dysfunction—a common cause of heart failure with preserved pumping capacity

More information: JAMA Cardiology (2018). DOI: 10.1001/jamacardio.2018.3539 , https://jamanetwork.com/journals/jamacardiology/fullarticle/2711896
Journal information: JAMA Cardiology

Citation: Biomarker discovered for most common form of heart failure (2018, October 31) retrieved 25 June 2019 from https://medicalxpress.com/news/2018-10-biomarker-common-heart-failure.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
18 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more