Antibiotic-resistant bacteria now claiming 33,000 lives annually

November 7, 2018, European Centre for Disease Prevention and Control (ECDC)
Error bars are 95% uncertainty intervals. Greece did not report data on S pneumoniae isolates to the European Antimicrobial Resistance Surveillance Network in 2015. DALY rates are age-standardised tolimit the effect of demographic differences across countries; numbers of cases and deaths are not age-standardised. DALYs=disability-adjusted life-years. *Excludes those resistant to carbapenem orcolistin. †In 2015, most of the third-generation cephalosporin-resistant E coli (88·6%) and K pneumoniae (85·3%) isolates reported to the European Antimicrobial Resistance Surveillance Networkproduced an extended-spectrum β-lactamase. Credit: ECDC/TLID

An ECDC study estimates the burden of five types of infections caused by antibiotic-resistant bacteria of public health concern in the European Union and in the European Economic Area (EU/EEA). The burden of disease is measured in number of cases, attributable deaths and disability-adjusted life years (DALYs). These estimates are based on data from the European Antimicrobial Resistance Surveillance Network (EARS-Net) data from 2015.

The authors said, "The estimated burden of infections with antibiotic-resistant in the EU/EEA is substantial compared to that of other infectious diseases, and increased since 2007. Strategies to prevent and control antibiotic-resistant bacteria require coordination at EU/EEA and global level. However, our study showed that the contribution of various to the overall burden varies greatly between countries, thus highlighting the need for prevention and control strategies tailored to the need of each EU/EEA country."

The study estimates that about 33,000 people die each year as a direct consequence of an infection due to bacteria resistant to antibiotics and that the burden of these infections is comparable to that of influenza, tuberculosis and HIV/AIDS combined. It also explains that 75 percent of the burden of disease is due to healthcare-associated infections (HAIs) and that reducing this through adequate prevention and control measures, as well as antibiotic stewardship, could be an achievable goal in healthcare settings.

Finally, the study shows that 39 percent of the burden is caused by infections with bacteria resistant to last-line antibiotics such as carbapenems and colistin. This is an increase from 2007, and is worrying because these antibiotics are the last treatment options available. When these are no longer effective, it is extremely difficult or, in many cases, impossible to treat infections.

Explore further: Superbugs killed 33,000 Europeans in 2015: study

More information: Alessandro Cassini et al, Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis, The Lancet Infectious Diseases (2018). DOI: 10.1016/S1473-3099(18)30605-4

Related Stories

Superbugs killed 33,000 Europeans in 2015: study

November 6, 2018
Drug-resistant bacteria killed more than 33,000 people in the European Union in 2015, according to new research published this week warning that superbugs were "threatening modern healthcare."

Antibiotic resistance increases relapse in urinary tract infections

October 30, 2018
Patients with a certain drug-resistant urinary tract infection were more likely to have a relapse of their infection within a week than those with non-resistant infections and were more likely to be prescribed an incorrect ...

Certain antibiotic-resistant infections on the rise, new research shows

August 21, 2018
Nearly six percent of urinary tract infections analyzed by a California emergency department were caused by drug-resistant bacteria in a one-year study period, according to new research in Annals of Emergency Medicine. The ...

CDC addresses burden, threat of antibiotic resistance

January 6, 2014
(HealthDay)—The burden and threats posed by antibiotic resistance infections are discussed in a report published by the U.S. Centers for Disease Control and Prevention.

Rise of carbapenem-resistant Enterobactericaeae

June 14, 2018
Infections with bacteria resistant to carbapenems, a group of highly effective antibiotics, pose a significant threat to patients and healthcare systems in all EU/EEA countries, warns ECDC in a Rapid Risk Assessment.

Researchers immunize mice against antibiotic-resistant bacteria, report potential for future vaccine

August 10, 2018
A groundbreaking study by LA BioMed researchers shows promising results for a potential vaccine for deadly drug-resistant bacteria, also known as "superbugs."

Recommended for you

Infants born to obese mothers risk developing liver disease, obesity

November 16, 2018
Infant gut microbes altered by their mother's obesity can cause inflammation and other major changes within the baby, increasing the risk of obesity and non-alcoholic fatty liver disease later in life, according to researchers ...

New study shows NKT cell subsets play a large role in the advancement of NAFLD

November 16, 2018
Since 2015 it has been known that the gut microbiota could have a direct impact on nonalcoholic fatty liver disease (NAFLD), which affects up to 12% of adults and is a leading cause of chronic liver disease. In the November ...

Antibiotic prescribing influenced by team dynamics within hospitals

November 15, 2018
Antibiotic prescribing by doctors is influenced by team dynamics and cultures within hospitals.

Zika may hijack mother-fetus immunity route

November 14, 2018
To cross the placenta, Zika virus may hijack the route by which acquired immunity is transferred from mother to fetus, new research suggests.

New research aims to help improve uptake of hepatitis C testing

November 14, 2018
New research published in Scientific Reports shows persisting fears about HIV infection may impact testing uptake for the hepatitis C Virus (HCV).

Maternally acquired Zika immunity can increase dengue disease severity in mouse pups

November 14, 2018
To say that the immune system is complex is an understatement: an immune response protective in one context can turn deadly over time, as evidenced by numerous epidemiological studies on dengue infection, spanning multiple ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

SANDROGREG
not rated yet Nov 07, 2018
God bless Dr Larry for his marvelous work in my life, I was diagnosed of HERPES SIMPLEX VIRUS since 2010 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr Larry, how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine within 3days. I took the medicine as prescribed by him and 2weeks later i was cured from HERPES contact him assurancesolutionhome@gmail com once again thanks to you Dr Larry. cure the flowing virus, contact his web site: or add him on whatsapp +1(424)-261-8520
1 cancer cure
2 diabetes cure
3 ringing ear
4 herpes cure
5 warts cure
6 HPV cure
7 HIV
8 get your ex back
9 pregnancy herbal medicine
10 prostate enlargement
11 Hepatitis

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.