Clinical and environmental factors impact absorption of common sunscreen ingredient

With the growing awareness of ultraviolet (UV) exposure resulting in an increased risk of photoaging and skin cancers, consumers are using higher sun protection factor (SPF) sunscreens with frequent reapplication. New research, Evaluation of Reapplication and Controlled Heat Exposure on Oxybenzone Permeation from Commercial Sunscreen Using Excised Human Abdominal Skin, presented today at the 2018 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 Meeting demonstrates that heat and reapplication influences different sunscreen products containing the same amount of a key ingredient, oxybenzone, potentially affecting safety and toxicity of the UV filters included in sunscreens.

"What our research shows is that current safety testing procedures may be underestimating the amount of oxybenzone being absorbed into the considering and reapplication, such as someone sunbathing on the beach," said presenting author, Paige Zambrana, a pharmaceutical sciences graduate student at the University of Maryland School of Pharmacy. "Although sunscreens are intended for the entire body under higher temperatures with reapplication every 80 minutes, safety testing for setting UV filter limits only require single dose testing under baseline skin temperature of 32 degrees Celsius."

The researchers performed in vitro permeation tests, which indicated that oxybenzone, using lotion and spray sunscreen formulations, was able to permeate human skin with significantly higher cumulative permeation occurring from the lotion. With the addition of 24-hour heat exposure on the lotion, there was a 2.1-fold increase in cumulative permeation of oxybenzone when comparing sunscreen reapplication at 80 min and 160 min, to a single application and a 1.2-fold increase in permeation when comparing 24-hour heat application to 24-hour baseline temperature sunscreen reapplication studies. When comparing formulations, applying lotion with 24-hour heat and reapplication significantly increased the cumulative oxybenzone permeation 3.1-fold more than the spray reapplication.

"Although sunscreen use is important and generally safe, our work suggests that some additional preclinical and clinical parameters should be considered before maximum UV filter levels are established," noted Audra Stinchcomb, Ph.D., principal investigator and professor of pharmaceutical sciences at the University of Maryland School of Pharmacy. "Also, given oxybenzone's potential environmental hazards and recently being banned in Hawaii, we are focused on how different factors affect people to provide accurate predictions of total oxybenzone absorption."

The next stage of this work will examine sunscreen use through controlled in vitro and in vivo testing procedures with the eventual aim of establishing an in vitro-in vivo correlation between the two tests. In addition, clinical trials with currently marketed sunscreen products will be performed to assess use conditions allowing for a better understanding of the current maximum absorption of oxybenzone.

Evaluation of Reapplication and Controlled Heat Exposure on Oxybenzone Permeation from Commercial Sunscreen Using Excised Human Abdominal Skin will be presented Wednesday, Nov. 7, 10:30 a.m. - 11:30 a.m. (EST) Poster Forum 5 the Walter E. Washington Convention Center.


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