Familial hypercholesterolemia in children and adolescents: diagnosis and treatment

Familial hypercholesterolemia is a hereditary genetic disorder predisposing in premature atherosclerosis and cardiovascular complications. Early diagnoses as well as effective treatment strategies in affected children are challenges among experts. Universal screening and cascade screening among families with familial hypercholesterolemia are being controversially discussed.

Treatment approaches for familial hypercholesterolemia in the pediatric population are multidisciplinary and aim to reduce total cardiovascular risk. Diagnosis of familial hypercholesterolemia in children and adolescents is usually based on clinical phenotype upon LDL-C levels and of premature cardiovascular and/or elevated LDL-C. The most widely recommended and effective pharmacotherapy in the pediatric age group is currently statins. Ezetimibe and bile acid sequestrants are usually used as second-line agents.

Evidence would be expected in the near future by cohort and registry studies. New therapeutic approaches, such as mipomersen and PCSK9 inhibitors seem promising. The main gap of evidence remains the lack of longitudinal follow up studies investigating cardiovascular outcomes, side effects, and effectiveness of treatment starting from childhood.


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Evidence insufficient to make recommendation regarding screening for lipid disorders in children

More information: Olga Maliachova et al, Familial Hypercholesterolemia in Children and Adolescents: Diagnosis and Treatment, Current Pharmaceutical Design (2018). DOI: 10.2174/1381612824666181010145807
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Citation: Familial hypercholesterolemia in children and adolescents: diagnosis and treatment (2019, January 2) retrieved 20 September 2019 from https://medicalxpress.com/news/2019-01-familial-hypercholesterolemia-children-adolescents-diagnosis.html
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