Searching for side effects

medication
Credit: CC0 Public Domain

Extracting relevant information from the scientific literature about side effects and adverse drug reactions to pharmaceutical products is an important part of data mining in this area. Writing in the International Journal of Data Mining and Bioinformatics, a team from China has developed a new search strategy that offers the optimal trade-off between retrieving pertinent abstracts and coping with the vast amounts of information available.

The team's "corpus-oriented perspective on terminologies" of side effect and ADRs could be, they suggest, an important tool in a thriving area of pharmaceutical research and development – drug repurposing.

Alex Chengyu Fang of the Department of Linguistics and Translation, at City University of Hong Kong, Yemao Liu, Yaping Lu, and Jingbo Xia of the College of Informatics at Huazhong Agricultural University, Jing Cao of Zhongnan University of Economics and Law, Wuhan, China, describe their approach as offering a useful compromise between the relevance of the content retrieved given a large body of work. The terms "" and "" are commonly used interchangeably and the latter might in some sense be considered a euphemism of the former term used by members of the public.

Indeed, side effects and ADRs are synonyms. The two, of course, have many hyponyms, terms that are essentially related to examples of both side effects and ADRs, which by definition are the hypernyms to those hyponyms. These terms too must be retrievable by any data mining algorithm that analyses a body of work and is intent on seeking relevant abstracts discussing the "hypernyms. Phrases such as "adverse drug event", " toxicity", "undesirable effects", and others all fall into the same clade and so must be involved in the retrieval.


Explore further

Predicting serious drug side effects before they occur

More information: Alex Chengyu Fang et al. A corpus-oriented perspective on terminologies of side effect and adverse reaction in support of text retrieval for drug repurposing, International Journal of Data Mining and Bioinformatics (2019). DOI: 10.1504/IJDMB.2018.097684
Provided by Inderscience
Citation: Searching for side effects (2019, February 12) retrieved 22 October 2019 from https://medicalxpress.com/news/2019-02-side-effects.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more