Ocular protein levels may be useful for Alzheimer testing

Ocular protein levels may be useful for alzheimer testing

(HealthDay)—Patients with poor cognitive function have significantly lower levels of Alzheimer disease-related biomarkers in the vitreous humor, according to a study published March 8 in the Journal of Alzheimer's Disease.

Lauren M. Wright, M.D., from the Boston University School of Medicine, and colleagues analyzed vitreous humor samples from 80 eyes of 80 individuals to quantify levels of beta amyloid-β (Aβ40, Aβ42), phosphorylated tau (pTau), and total tau (tTau). Serum was also used to determine apolipoprotein E (APOE) status. Participants underwent testing with the Mini-Mental State Exam (MMSE).

The researchers found that lower MMSE scores were significantly associated with lower levels of vitreous Aβ40 (P = 0.015), Aβ42 (P = 0.0066), and tTau (P = 0.0085). There was no association between these biomarkers and any preexisting eye conditions. There was a trend toward an association between the presence of the ε4 allele and the ε2 allele with reduced Aβ40 level (P = 0.053) and increased p-Tau level (P = 0.056), respectively.

"Results suggest ocular proteins may have a role for early dementia detection in individuals at-risk for Alzheimer disease," the authors write.

More information: Abstract/Full Text (subscription or payment may be required)

Journal information: Journal of Alzheimer's Disease

Copyright © 2019 HealthDay. All rights reserved.

Citation: Ocular protein levels may be useful for Alzheimer testing (2019, March 25) retrieved 23 June 2024 from https://medicalxpress.com/news/2019-03-ocular-protein-alzheimer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

AAIC: Turnover kinetics vary for different amyloid beta isoforms


Feedback to editors