Researchers relate DNA methylation levels to obesity

Researchers relate DNA methylation levels to obesity
Diagram of metabolic pathways followed by fat until it reaches the cells that regulate it . Credit: University of Malaga

DNA methylation is a mechanism that regulates whether genes are "on" or "off", and is influenced by hereditary and environmental factors, as well as lifestyle and nutritional habits.

This research evidences that methylation levels in the gene involved in -Lipoprotein lipase (LPL)- are higher in obese people with a in contrast to healthy people. "Since this gene is essential to decide whether the fat ingested is stored or consumed by the tissues, a dysfunction of this gene would cause high levels of triglycerides in blood", explains the main author, Daniel Castellano.

In this regard, experts alert that dysfunctional lipid metabolism in obesity is associated with a higher systemic inflammation, diabetes, cardiovascular disease or even cancer.

Likewise, this study also describes a lower DNA methylation in a gene related to inflammatory processes, such as the (TNF), which may cause a higher functioning of this gene, which, in turn, may affect the pro-inflammatory condition observed in obese people with a metabolic disease.

Consequently, the main researchers of the study, Fernando Cardona and María Isabel Queipo, both members of Group A02 of the Biomedical Research Institute of Malaga (IBIMA), coordinated by Francisco José Tinahones, conclude that the methylation levels of genes related to lipid metabolism and inflammation are altered in obese patients with a metabolic disease, which partially explains the development of this disease.

The importance of epigenetic regulation

Thus, they point out the importance of epigenetic regulation in the origin of metabolic diseases and affirm that the study of epigenetic mechanisms is essential for developing new therapeutic strategies to face these pathologies, as well as for determining lifestyle habits that may prevent these alterations in DNA methylation.


Explore further

Lifestyle influences metabolism via DNA methylation

More information: Daniel Castellano-Castillo et al. Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables, Journal of Clinical Medicine (2019). DOI: 10.3390/jcm8010087
Provided by University of Malaga
Citation: Researchers relate DNA methylation levels to obesity (2019, April 10) retrieved 26 June 2019 from https://medicalxpress.com/news/2019-04-dna-methylation-obesity.html
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