Maternal blood test is effective for Down syndrome screening in twin pregnancies

Cell-free DNA (cfDNA) testing, which involves analyzing fetal DNA in a maternal blood sample, is a non-invasiveness and highly accurate test for Down syndrome in singleton pregnancies, but its effectiveness in twin pregnancies has been unclear. A new analysis published in Ultrasound in Obstetrics & Gynecology reveals that cfDNA testing for Down syndrome in twins is just as effective as in singletons, with a detection rate of 98% and only a 0.05% rate of misdiagnosis.

The analysis combined information from a dataset of 997 twin pregnancies in addition to results from seven previously published studies.

In many countries, including the United States, cfDNA testing is not recommended for use in . These latest findings provide compelling evidence that mothers carrying twins should not be denied this safe and effective test.


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More information: Ultrasound in Obstetrics & Gynecology, DOI: 10.1002/uog.20284
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Citation: Maternal blood test is effective for Down syndrome screening in twin pregnancies (2019, June 5) retrieved 13 June 2021 from https://medicalxpress.com/news/2019-06-maternal-blood-effective-syndrome-screening.html
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