SGLT2 inhibitors protect against kidney disease in T2DM

SGLT2 inhibitors protect against kidney disease in T2DM

(HealthDay)—A class of diabetes drugs, called sodium-glucose co-transporter-2 (SGLT2) inhibitors, protect against kidney disease in patients with type 2 diabetes, according to a review published online Sept. 5 in The Lancet Diabetes & Endocrinology.

Brendon L. Neuen, M.B.B.S., from the University of New South Wales in Sydney, and colleagues conducted a systematic literature review to identify randomized, controlled trials of SGLT2 inhibitors that reported effects on major kidney outcomes in people with type 2 diabetes.

The researchers identified four studies that assessed three SGLT2 inhibitors: empagliflozin, canagliflozin, and dapagliflozin. Among 38,723 participants, the researchers found that 252 patients required dialysis, transplantation, or died of kidney disease; 335 developed end-stage kidney disease; and 943 had . There was a substantial reduction in the risk of dialysis, transplantation, or death due to kidney disease (relative risk, 0.67) with SGLT2 inhibitors. There was also a reduction in end-stage (relative risk, 0.65) and acute kidney injury (relative risk, 0.75) with SGLT2 inhibitors. A benefit was seen for all estimated glomerular filtration rate and albuminuria subgroups.

"These data provide substantive evidence supporting the use of SGLT2 inhibitors to prevent major kidney outcomes in people with type 2 diabetes," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.


Explore further

New study confirms protective effect of diabetes drugs against kidney failure

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2019 HealthDay. All rights reserved.

Citation: SGLT2 inhibitors protect against kidney disease in T2DM (2019, October 11) retrieved 15 November 2019 from https://medicalxpress.com/news/2019-10-sglt2-inhibitors-kidney-disease-t2dm.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments