An artificial neural connection allows a new cortical site to control hand movements

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Restoration of lost motor function after stroke is typically accomplished after strenuous rehabilitation therapy lasting for over months. However, new research published by a group led by Yukio Nishimura, the project leader of the Neural Prosthesis Project, Tokyo Metropolitan Institute of Medical Science, showed that an artificial neural connection (ANC) successfully allowed a new cortical site, previously unassociated with hand movements, to regain control of a paralyzed hand in a matter of minutes.

In this research, experimental animals regained voluntary control of a paralyzed hand about ten minutes after establishment of an ANC. Animals engaged in learning with a functional ANC showed variable levels of input signals provided by the as hand movement improved. Specifically, the activated area of the cortex became more focused as control of hand movements improved.

Through this training of various areas of the cerebral cortex, the research team successfully imparted a new ability to control paralyzed hands via an ANC, even if those areas were not involved in hand control prior to the stroke. Examples of such regions include areas of the cortex that control the movement of other such as the face or shoulder, and even the , which is responsible for tactile and proprioception processing, and is normally not associated with motor control. This finding suggests that an ANC can impart new functions to any cortical region.

This research will contribute to the development of innovative therapies that will help stroke patients regain lost motor function by imparting this function to regions of the cerebral cortex previously not associated with hand movement. It is expected that these therapies will have practical clinical applications beyond restoring and lead to the development of novel techniques to further integrate with computers. The researchers will continue to investigate whether extended use of an ANC will enhance the activity of spared neural networks and facilitate functional recovery so that patients will be able to regain voluntary control of paralyzed body parts even if they discontinue using the ANC.

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More information: Kenji Kato et al, Bypassing stroke-damaged neural pathways via a neural interface induces targeted cortical adaptation, Nature Communications (2019). DOI: 10.1038/s41467-019-12647-y
Journal information: Nature Communications

Provided by Tokyo Metropolitan Institute of Medical Science
Citation: An artificial neural connection allows a new cortical site to control hand movements (2020, January 7) retrieved 5 July 2022 from
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