Stress-related disorders linked to neurodegenerative disease

Stress-related disorders linked to neurodegenerative disease

(HealthDay)—Stress-related disorders are associated with an increased risk for neurodegenerative diseases, according to a study published online March 9 in JAMA Neurology.

Huan Song, M.D., Ph.D., from West China Hospital in Chengdu, and colleagues examined the association between and risk for in a population-matched and sibling cohort study. The population-matched cohort included 61,748 exposed individuals matched with 595,335 unexposed individuals; the sibling cohort analysis included 44,839 exposed individuals and their 78,482 unaffected full siblings.

The researchers found that individuals with a stress-related disorder were at an for neurodegenerative disease compared with unexposed individuals (hazard ratio [HR], 1.57; 95 percent confidence interval [CI], 1.43 to 1.73). A greater risk increase was seen for vascular neurodegenerative diseases than primary neurodegenerative diseases (HRs, 1.80 [95 percent CI, 1.40 to 2.31] and 1.31 [95 percent CI, 1.15 to 1.48], respectively). A statistically significant association was seen for Alzheimer disease (HR, 1.36; 95 percent confidence interval, 1.12 to 1.67), but the associations were not significant for Parkinson disease (HR, 1.20; 95 percent CI, 0.98 to 1.47) or (HR, 1.20; 95 percent CI, 0.74 to 1.96).

"The underlying mechanisms behind this association, primarily the role of cerebrovascular factors, warrant further studies," the authors write.

One author disclosed financial ties to the biopharmaceutical industry.

More information: Abstract/Full Text (subscription or payment may be required)

Journal information: Archives of Neurology

Copyright © 2020 HealthDay. All rights reserved.

Citation: Stress-related disorders linked to neurodegenerative disease (2020, March 9) retrieved 23 March 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Risk for birth defects not increased with adalimumab


Feedback to editors