Management of Sjögren's syndrome with topical and systemic therapies

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The European League Against Rheumatism, EULAR, has published recommendations for the management of patients with Sjögren's syndrome with topical and systemic therapies.

The therapeutic management of Sjögren's syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this, EULAR supported an international to develop evidence-based and consensus-based recommendations for the management of patients with SjS with topical and systemic medications.

The task force developed three overarching principles and 12 specific recommendations for management of SjS. The recommendations form a logical sequence, starting with the management of the central triplet of symptoms (dryness, fatigue and pain) followed by the management of systemic .

The three overarching principles are:

  1. Patients with SjS should be managed at, or in close collaboration with, centres of expertise using a multidisciplinary approach.
  2. The first therapeutic approach to dryness should be symptomatic relief using topical therapies.
  3. Systemic therapies may be considered for the treatment of active systemic disease.

The 12 specific recommendations are:

  1. Baseline evaluation of salivary gland function is recommended before starting treatment for oral dryness.
  2. The preferred first therapeutic approach for oral dryness according to salivary gland function may be: Non-pharmacological stimulation for mild dysfunction; pharmacological stimulation for moderate dysfunction; saliva substitution for severe dysfunction.
  3. The first-line therapeutic approach to ocular dryness includes artificial tears and ocular gels/ointments.
  4. Refractory/severe ocular dryness may be managed using topical immunosuppressive-containing drops and serum eye drops.
  5. Concomitant diseases should be evaluated in patients presenting with fatigue/pain, whose severity should be scored using specific tools.
  6. Consider analgesics or other pain-modifying agents for musculoskeletal pain, taking into account the balance between potential benefits and side-effects.
  7. Treatment of systemic disease should be tailored to organ-specific severity using the EULAR Sjögren's Syndrome disease activity index ESSDAI definitions.
  8. Glucocorticoids (GCs) should be used at the minimum dose and length of time necessary to control active systemic disease.
  9. Synthetic immunosuppressive agents should mainly be used as GC-sparing agents, with no evidence supporting the choice of one agent over another.
  10. B-cell targeted therapies may be considered in patients with severe, refractory systemic disease.
  11. The systemic organ-specific may, as a general rule, follow the sequential (or combined) use of GCs, immunosuppressive agents and biologics.
  12. Treatment of B-cell lymphoma should be individualised according to the specific histological subtype and disease stage.

Sjögren's syndrome, a systemic autoimmune disease that affects between one and 23 people per 10,000 inhabitants in European countries, presents with a wide spectrum of clinical manifestations and autoantibodies. Antinuclear antibodies are the most frequently detected autoantibodies, anti-Ro/SS-A the most specific, and cryoglobulins and hypocomplementaemia the main prognostic markers.

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Provided by European League Against Rheumatism (EULAR)
Citation: Management of Sjögren's syndrome with topical and systemic therapies (2020, April 2) retrieved 24 January 2021 from
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