Suppressing stomach acid may up intestinal growth of MDROs

Suppressing stomach acid may up intestinal growth of MDROs

(HealthDay)—Stomach acid suppression medications increase the odds of intestinal colonization with multidrug-resistant microorganisms (MDROs), according to a review and meta-analysis recently published in JAMA Internal Medicine.

Roel P.J. Willems, M.D., from the Amsterdam University Medical Centers, and colleagues analyzed data from 26 to examine the association between the use of gastric acid suppressants and the risk of intestinal colonization with MDROs.

The researchers found that 38.9 percent of patients in the included studies were acid suppressant users. Among the 22,305 patients who were included in a primary meta-analysis, acid suppression increased the odds of intestinal carriage of MDROs of the Enterobacterales order and of vancomycin-resistant enterococci by 75 percent (odds ratio, 1.74). A pooled analysis including 29,382 supported this finding (odds ratio, 1.70). Variations in study setting and the type of acid suppression partially explained heterogeneity.

"While proton pump inhibitors are generally safe, even rare infectious and noninfectious adverse events are important on a given their wide use," write the authors of an accompanying editorial. "It is well established that are overprescribed, and given their known association with a variety of adverse reactions, the important issue is how we can decrease inappropriate use."

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Journal information: JAMA Internal Medicine

Copyright © 2020 HealthDay. All rights reserved.

Citation: Suppressing stomach acid may up intestinal growth of MDROs (2020, April 9) retrieved 8 June 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Gastric medications increase risk for recurrence of Clostridium difficile infection


Feedback to editors