Smoking tied to inferior survival in acute myeloid leukemia

Smoking tied to inferior survival in acute myeloid leukemia

Smoking status is an important patient-related prognostic factor for outcome in patients with acute myeloid leukemia (AML) treated with intensive chemotherapy, according to a study published online April 21 in the British Journal of Haematology.

Daniel Kristensen, M.D., from Aalborg University Hospital in Denmark, and colleagues conducted a nationwide cohort study based on data from the Danish National Leukaemia Registry to examine the prognostic impact of smoking status in patients with AML treated with intensive chemotherapy. Data were included for 1,040 patients diagnosed with AML between Jan. 1, 2000, and Dec. 31, 2012; of these patients, 58.9 percent were classified as ever-smokers.

The researchers found that ever-smokers had a significantly shorter compared with never-smokers (17.2 versus 24.5 months). Smoking status was a significant prognostic factor for inferior overall survival in a multivariate analysis (hazard ratio, 1.22).

"Due to the observational and hypothesis-generating character of this study, it remains uncertain whether tobacco- affects overall survival in patients with AML through leukemia-related (e.g., ) or patient-related (e.g., pulmonary morbidity) factors," the authors write. "We suggest that future studies on this subject should aim to include socio-economic and leukemia-related prognostic factors to study the exact mechanism of inferior survival in previous and current smokers with AML."

One author was employed by Roche Ltd.

Explore further

Blast count prognostic for CML presenting in advanced phase

More information: Abstract/Full Text
Journal information: British Journal of Haematology

Copyright © 2020 HealthDay. All rights reserved.

Citation: Smoking tied to inferior survival in acute myeloid leukemia (2020, April 30) retrieved 29 May 2020 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments