Regulation of cancer stemness by the best combination of nanotech and genetic engineering

Regulation of cancer stemness by the best combination of nanotech and genetic engineering
Mechanism of cancer cell death triggered by photo-thermal property of CNH and temperature sensitive TRPV2-mediated Ca2+ overdosing. Credit: JAIST

The development of chemotherapeutic agents with selective anti-cancer activities is increasingly unattractive due to the emergence of resistance, poor targeting of cancer tissues, and subsequent metastasis. Among tumor characteristic cell types, cancer stem cells are increasingly associated with cancer progression and metastasis, reflecting self-renewal and their propensity to enter the circulation.

Scientists at Japan Advanced Institute of Science and Technology (JAIST) have created a regulation technology of fatal cancer stemness using the combination of nanotechnology and genetic engineering called as 'photothermogenetics' that allows for effective cancer elimination.

Developed by Associate Professor Eijiro Miyako and his team from JAIST, photo-active functional nanocarbon complexes, which made of (PEG)-modified carbon nanohorns (CNH) with an antibody against the receptor potential vanilloid family type 2 (TRPV2), showed high potential as a targeting cancer chemotherapeutic agent.

In fact, the nanocomplexes are effectively heated by biologically permeable near-infrared light. After application to and mice tumor models, these complexes photo-thermally triggered calcium influx into target cells overexpressing TRPV2 (temperature-responsive membrane protein), resulting in increased cancer cell death and effective regulation of cancer stemness. The present experiments warrant further consideration of this novel chemotherapeutic approach using the best combination of nanotechnology and for the treatment of refractory cancers and control of fatal cancer stemness.


Explore further

Multi-functionalization of graphene for molecular targeted cancer therapy

More information: Yue Yu et al, Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes, Nature Communications (2020). DOI: 10.1038/s41467-020-17768-3
Journal information: Nature Communications

Provided by Japan Advanced Institute of Science and Technology
Citation: Regulation of cancer stemness by the best combination of nanotech and genetic engineering (2020, August 17) retrieved 29 October 2020 from https://medicalxpress.com/news/2020-08-cancer-stemness-combination-nanotech-genetic.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
2 shares

Feedback to editors

User comments