Prophylactic steroids may prevent complications of thyroidectomy

Prophylactic steroids may prevent complications of thyroidectomy

(HealthDay)—A single preoperative dose of dexamethasone reduces rates of postoperative hypocalcemia and voice dysfunction in patients undergoing thyroidectomy, according to a study published online Sept. 2 in JAMA Otolaryngology-Head & Neck Surgery.

Adeel Abbas Dhahri, from the Royal Infirmary Hospital of Edinburgh in the United Kingdom, and colleagues randomly assigned 192 who were undergoing thyroidectomy to a single preoperative intravenous dose of either dexamethasone or normal saline (96 patients in each group). Postoperative rates of hypocalcemia and voice dysfunction were the primary outcomes.

The researchers found that in the first 24 hours after thyroidectomy, 24.4 percent of patients developed hypocalcemia and 9.4 percent were symptomatic. At three days postthyroidectomy, hypocalcemia was seen in four of 96 patients in the placebo group and none in the dexamethasone group. At 24 hours postthyroidectomy, 8.3 percent of dexamethasone patients had voice dysfunction versus 33.3 percent in the .

"This randomized clinical trial demonstrated that a single 8-mg dose of dexamethasone during the preoperative period was safe and effective in improving transient, immediate postoperative hypocalcemia as well as temporary voice dysfunction in patients undergoing thyroidectomy," the authors write.

Explore further

Thyroidectomy-specific quality improvement measures ID'd

More information: Abstract/Full Text (subscription or payment may be required)

Copyright © 2021 HealthDay. All rights reserved.

Citation: Prophylactic steroids may prevent complications of thyroidectomy (2021, September 20) retrieved 20 January 2022 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors