Fat cells found to play a central role in cognitive decline and neurodegeneration

cognitive function
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Findings published this week reveal new insights into the role of fat cells in cognitive decline and neurodegeneration, according to a study that involves the oxidant amplification loop led by Marshall University scientists.

The research, published in iScience, shows that fat cells control the systemic response to , causing impairment in memory and cognition in mice. The activation of Na,K-ATPase oxidant amplification loop affects the expression of important protein markers in fat cells as well as in the hippocampus, which can worsen brain function and lead to neurodegeneration. Targeting the fat cells to antagonize Na,K-ATPase may improve these outcomes. 

"We have aimed to demonstrate that Na,K-ATPase signaling, specifically in adipocytes, play a central role in inducing alterations in specific regions of the brain, most notably in the hippocampus, which is critical to memory and cognitive function," said senior author Joseph I Shapiro, M.D., professor and dean of the Marshall University Joan C. Edwards School of Medicine.

Researchers used a genetically-modified mouse model that released the peptide NaKtide specifically in adipocytes, or fat cells, to find that NaKtide inhibited the signaling function of Na,K-ATPase. The adipocyte-specific NaKtide expression improved the altered phenotype of adipocytes and improved function of the hippocampus, the part of the brain associated with memory and cognition. Inducing through increased production of inflammatory cytokines confined to adipocytes as well as altered protein markers of memory and cognition in the hippocampus. 

"Western diet induces oxidant stress and adipocyte alteration through Na,K-ATPase signaling which causes systemic inflammation and affects behavioral and brain biochemical changes," said Komal Sodhi, M.D., first author and associate professor of surgery and at the Joan C. Edwards School of Medicine. "Our study showed that adipocyte-specific NaKtide expression in our murine model ameliorated these changes and improved neurodegenerative phenotype."


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More information: Komal Sodhi et al, Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in Cognitive Decline and Neurodegeneration, iScience (2021). DOI: 10.1016/j.isci.2021.103262
Journal information: iScience

Provided by Marshall University Joan C. Edwards School of Medicine
Citation: Fat cells found to play a central role in cognitive decline and neurodegeneration (2021, October 22) retrieved 26 November 2021 from https://medicalxpress.com/news/2021-10-fat-cells-central-role-cognitive.html
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