Study offers hope for preventing cerebral palsy

pre term baby
Credit: Unsplash/CC0 Public Domain

Severe brain injury that develops slowly after preterm births, causing cerebral palsy, may be treatable, new research from the University of Auckland finds.

More than a third of cases of cerebral palsy are still linked to being born extremely prematurely. Clinical studies have shown that can appear many weeks after birth. "The current thinking is that this form of brain injury is so severe that there is no point trying to understand it, let alone treat it," says senior research fellow Dr. Christopher Lear, lead author on the new study. "Just the concept that it might be treatable is revolutionary."

The University of Auckland team showed, in an , that there was intense local inflammation before the injury developed.

Critically, giving the well-established anti-inflammatory drug, Etanercept (also known as "Enbrel") three days after a period of oxygen deprivation was able to almost completely prevent severe injury from developing after three weeks' recovery. The article has just been published in the journal Brain.

"Virtually all proposed treatments so far need to be started within the first six hours of life," says Professor Laura Bennet. "This is often not realistic when families are overwhelmed by events around birth."

"A of at least three days is exceptionally long. Much more research is needed before this approach can be tested in humans, but this remarkably wide window for treatment gives us real hope that these findings will one day lead to a new treatment in humans to prevent cerebral palsy," says Professor Bennet.

The team are from the Fetal Physiology and Neuroscience Group in the Department of Physiology.

More information: Christopher A Lear et al, Tumour necrosis factor blockade after asphyxia in foetal sheep ameliorates cystic white matter injury, Brain (2022). DOI: 10.1093/brain/awac331
Journal information: Brain

Citation: Study offers hope for preventing cerebral palsy (2022, September 29) retrieved 2 December 2022 from
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