Blood pressure medication effective at any time of day: Large clinical trial overturns previous research

taking a blood pressure
Credit: Unsplash/CC0 Public Domain

Medication that lowers blood pressure is equally effective if taken in the morning or evening, a large clinical trial has found.

This overturns previous research that suggested -lowering medication may be more effective if taken in the evening.

Blood pressure-lowering medications are among the most widely prescribed in the U.K., with between seven and nine million people taking them to reduce their risk of developing heart and circulatory diseases.

Clinical trial

This new randomized-controlled trial of more than 21,000 patients with found that protection against , stroke or circulatory diseases is not affected by whether blood pressure drugs are taken in the morning or evening.

Participants in the trial were taking at least one medication to lower their blood pressure. Half were asked to take their in the evening and the other half were asked to take it in the morning.

After following those on trial for five years, it was found that there was no difference in the number of people who had a heart attack, stroke or circulatory diseases—362 in the morning group versus 390 in the evening.

The research was carried out by teams from Universities of Edinburgh, Dundee, Glasgow and Oxford, Imperial College London, and Queen Mary University of London.

The study has been published in The Lancet.

"The main message from the study is that there is no optimal time to take blood pressure tablets to achieve a better outcome, so patients should take their tablets at the time that suits them best," says Professor David Webb, Christison Chair of Therapeutics and Clinical Pharmacology and author on the study.

More information: Isla S Mackenzie et al, Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial, The Lancet (2022). DOI: 10.1016/S0140-6736(22)01786-X

Journal information: The Lancet
Citation: Blood pressure medication effective at any time of day: Large clinical trial overturns previous research (2022, October 18) retrieved 18 April 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Evening dosing of blood pressure medication not better than morning dosing


Feedback to editors