Gastroesophageal reflux disease causally linked to lung cancer

Gastroesophageal reflux disease causally linked to lung cancer

Gastroesophageal reflux disease (GERD) is causally associated with lung cancer risk, according to a study published online Dec. 8 in Cancer Medicine.

Lin Li, from The Second Affiliated Hospital of Zunyi Medical University in China, and colleagues employed a two-sample Mendelian randomization (MR) approach to examine the between GERD and lung cancer. Independent single nucleotide polymorphisms that were highly linked to GERD were identified in a sample of 129,080 GERD patients. Data from were used to assess outcomes for lung cancer, including squamous cell lung cancer (LUSC) and lung adenocarcinoma (LUAD) in 11,348 patients. To examine the potential causative association between GERD and risk for lung cancer, three MR statistical techniques were used.

The researchers found that based on the main inverse variance weighted (IVW) method, GERD substantially increased lung cancer risk (odds ratio, 1.37); this was also supported in weighted median and MR-Egger analyses. Similar causal relationships were seen between GERD and LUSC and LUAD (odds ratios, 1.56 and 1.45, respectively) using IVW estimates. In some studies, potential heterogeneity was observed; however, random effect IVW was not violated by the heterogeneity, indicating the robustness of the causal effect.

"This study bolstered the case for a genetic link between GERD susceptibility and lung cancer," the authors write. "Considering the high mortality and morbidity associated with lung cancer patients, it is of significance to recognize and control the risk factor of GERD for in order to decrease its prevalence."

More information: Lin Li et al, Causal associations between gastroesophageal reflux disease and lung cancer risk: A Mendelian randomization study, Cancer Medicine (2022). DOI: 10.1002/cam4.5498

Journal information: Cancer Medicine

Copyright © 2022 HealthDay. All rights reserved.

Citation: Gastroesophageal reflux disease causally linked to lung cancer (2022, December 30) retrieved 20 April 2024 from https://medicalxpress.com/news/2022-12-gastroesophageal-reflux-disease-causally-linked.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Gastroesophageal reflux disease raises risk for periodontitis: Study

21 shares

Feedback to editors