This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:


trusted source


Vitamin A may protect the heart from some effects of obesity

vitamin A
Credit: Pixabay/CC0 Public Domain

Research in a mouse model of diet-induced obesity has found greater disruption to genes involved in heart function when coupled with vitamin A deficiency using a combined dietary and genetic approach. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology.

The research team, based at Hannover Medical School in Germany, induced obesity in a mouse model of vitamin A deficiency. After 20 weeks, the researchers compared the hearts and metabolism of the mice to with sufficient levels of vitamin A. In comparison, the vitamin-deficient obese mice had repression of genes in the heart that are associated with extracting energy from fat, extracting energy from glucose, and the production of the energy-carrying molecule adenosine triphosphate.

All of these areas are critical to metabolic functioning.

"Our study identifies a role for vitamin A in preserving cardiac energetic gene expression that might attenuate subsequent development of mitochondrial and contractile dysfunction in diet-induced obesity," the researchers wrote.

More information: Lea Naasner et al, Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity, American Journal of Physiology-Heart and Circulatory Physiology (2022). DOI: 10.1152/ajpheart.00514.2022

Citation: Vitamin A may protect the heart from some effects of obesity (2023, January 26) retrieved 25 July 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

How obesity affects vitamin D metabolism


Feedback to editors