Researchers identify compounds that could lead to an on-demand, short-term contraceptive for men

In a mouse study, researchers have identified a potential non-hormonal contraceptive that men could take shortly before sexual activity and have fertility restored the next day.

Researchers gave male mice a compound that temporarily disables soluble adenylyl cyclase, the enzyme essential for activating a sperm cell's ability to swim and mature so that it can travel through the female reproductive tract and fertilize an egg.

In several tests, the researchers showed that the compound TDI-11861 rendered mouse sperm cells immobile and prevented them from maturing. The compounds did not interfere with the animals' sexual functioning. Although male mice mated with females, no pregnancies were observed. Sperm recovered from female mice remained incapacitated. The authors did not observe any side effects in the male or female mice. The compound wore off three hours later, and males recovered their fertility.

The study was conducted by Melanie Balbach, Ph.D., a postdoctoral fellow in the laboratories of co-authors Jochen Buck, Ph.D., and Lonnie Levin, Ph.D., at Weill Cornell Medical College, New York City, and colleagues. It appears in Nature Communications.

The researchers say their work provides proof of concept that soluble adenylyl cyclase inhibitors have the potential to provide a safe, on-demand, non-hormonal and reversible oral contraceptive for men.

The article "On-demand male contraception via acute inhibition of soluble adenylyl cyclase" is published in Nature Communications on February 14, 2023.