This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

trusted source

proofread

Researchers identify compounds that could lead to an on-demand, short-term contraceptive for men

sperm
Credit: Pixabay/CC0 Public Domain

In a mouse study, researchers have identified a potential non-hormonal contraceptive that men could take shortly before sexual activity and have fertility restored the next day.

Researchers gave male mice a compound that temporarily disables soluble adenylyl cyclase, the enzyme essential for activating a sperm cell's ability to swim and mature so that it can travel through the and fertilize an egg.

In several tests, the researchers showed that the compound TDI-11861 rendered mouse sperm cells immobile and prevented them from maturing. The compounds did not interfere with the animals' sexual functioning. Although mated with females, no pregnancies were observed. Sperm recovered from female mice remained incapacitated. The authors did not observe any in the male or female mice. The compound wore off three hours later, and males recovered their fertility.

The study was conducted by Melanie Balbach, Ph.D., a postdoctoral fellow in the laboratories of co-authors Jochen Buck, Ph.D., and Lonnie Levin, Ph.D., at Weill Cornell Medical College, New York City, and colleagues. It appears in Nature Communications.

The researchers say their work provides proof of concept that soluble adenylyl cyclase inhibitors have the potential to provide a safe, on-demand, non-hormonal and reversible oral contraceptive for men.

The article "On-demand male contraception via acute inhibition of soluble adenylyl cyclase" is published in Nature Communications on February 14, 2023.

More information: Jochen Buck, On-demand male contraception via acute inhibition of soluble adenylyl cyclase, Nature Communications (2023). DOI: 10.1038/s41467-023-36119-6. www.nature.com/articles/s41467-023-36119-6

Journal information: Nature Communications
Citation: Researchers identify compounds that could lead to an on-demand, short-term contraceptive for men (2023, February 14) retrieved 29 May 2024 from https://medicalxpress.com/news/2023-02-compounds-on-demand-short-term-contraceptive-men.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Researchers identify protein FER1L5 as essential for male fertility in mice

4 shares

Feedback to editors