This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

trusted source

proofread

Research suggests commonly-used herbicide is harmful to adolescent brain function

Commonly used herbicide is harmful to adolescent brain function
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science researchers measured concentrations of popular herbicides and the insect repellent DEET in urine samples of adolescents living in the agricultural county of Pedro Moncayo, Ecuador to evaluate their impact on the adolescent brain. Credit: Briana Chronister, UC San Diego

Herbicides are the most used class of pesticides worldwide, with uses in agriculture, homes and industry. Exposures to two of the most popular herbicides were associated with worse brain function among adolescents, according to a study led by researchers at the Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego.

In the Oct. 11, 2023 online issue of Environmental Health Perspectives, the researchers reported measuring metabolite concentrations of two commonly used herbicides—glyphosate and 2,4-dichlorophenoxyacetic acid (2,4D)—and the insect repellent DEET in collected in 2016 from 519 adolescents, aged 11 to 17, living in the agricultural county of Pedro Moncayo, Ecuador. Researchers also assessed neurobehavioral performance in five areas: attention and , memory and learning, language, visuospatial processing, and social perception.

"Many and in adolescents and young adults have increased over the last two decades worldwide, and exposure to neurotoxic contaminants in the environment could explain a part of this increase," said senior author Jose Ricardo Suarez, M.D., Ph.D., M.P.H., associate professor in the Herbert Wertheim School of Public Health.

Among the findings:

  • Glyphosate, a nonselective herbicide used in many crops, including corn and soy, and for vegetation control in residential settings, was detected in 98% of participants.
  • 2,4D, a broadleaf herbicide used on lawns, aquatic sites, and , was detected in 66% of participants.
  • Higher amounts of 2,4D in urine were associated with lower neurobehavioral performance in the domains of attention and inhibitory control, memory and learning, and language.
  • Glyphosate concentration in urine was associated with lower scores in social perception only, while DEET metabolites were not associated with neurobehavioral performance.

Following the introduction of genetically modified, glyphosate-resistant "Roundup-ready" crops in 1996 and 2,4D resistant crops in 2014, there have been substantial increases in glyphosate and 2,4D use, making them the most widely used herbicides in the world, wrote the authors.

"There is considerable use of and insecticides in agricultural industries in both developed and developing nations around the world, raising exposure potential for children and adults, especially if they live in , but we don't know how it impacts each stage of life," said first author Briana Chronister, doctoral candidate in the UC San Diego—San Diego State University Joint Doctoral Program in Public Health.

Previous studies have linked exposure to some of the most used insecticides to altered neurocognitive performance while other insecticides may also affect mood and brain development. Today, 20% of adolescents and 26% of have diagnosable mental health conditions such as anxiety, depression, impulsivity, aggression or learning disorders.

The authors reported that 2,4D was negatively associated with performance in all five neurobehavioral areas, but statistically significant associations were observed with attention and inhibitory control, memory and learning, and language. Glyphosate had a significant negative association only with social perception, a test that measures the ability to recognize emotions, while DEET metabolites were not associated with neurobehavioral alterations.

"Hundreds of are released into the market each year, and more than 80,000 chemicals are registered for use today," said Suarez. "Sadly, very little is known about the safety and long-term effects on humans for most of these chemicals. Additional research is needed to truly understand the impact."

This research is a study within ESPINA: The Study of Secondary Exposures to Pesticides Among Children and Adolescents, a prospective cohort study. ESPINA aims to understand the effect of pesticide exposures on the development of humans from childhood thru adulthood.

In 2022, Suarez and his team completed year 14 of follow-up of study participants with plans to evaluate whether the observed associations persist into early adulthood.

Co-authors include: Kun Yang, Audrey R. Yang, Tuo Lin, Xin Tu, Harvey Checkoway, Jose Suarez-Torres, Sheila Gahagan, and Raeanne C. Moore, UC San Diego; Dolores Lopez-Paredes and Danilo Martinez, Fundación Cimas del Ecuador; and Dana Barr, Emory University.

More information: Briana Chronister et al, Urinary glyphosate, 2,4-D and DEET biomarkers in relation to neurobehavioral performance in Ecuadorian adolescents in the ESPINA cohort, Environmental Health Perspectives (2023). DOI: 10.1289/EHP11383

Citation: Research suggests commonly-used herbicide is harmful to adolescent brain function (2023, October 11) retrieved 28 February 2024 from https://medicalxpress.com/news/2023-10-commonly-used-herbicide-adolescent-brain-function.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Dread of roses: Neurobehavioral effects found in children exposed to flower pesticides

694 shares

Feedback to editors