This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

trusted source

proofread

Mobile stroke units increase odds of averting stroke

Mobile stroke units increase odds of averting stroke
Mobile stroke units bring the the emergency room to the patient including a CAT scan machine, clot-busting medication and video link to doctors. Credit: NewYork-Presbyterian

Receiving a clot-busting drug in an ambulance-based mobile stroke unit (MSU) increases the likelihood of averting strokes and complete recovery compared with standard hospital emergency care, according to researchers at Weill Cornell Medicine, New York-Presbyterian, UTHealth Houston, Memorial Hermann-Texas Medical Center and five other medical centers across the United States.

The study, published online in the Annals of Neurology on Oct. 6, determined that MSU care was associated with both increased odds of averting stroke compared with hospital emergency (EMS)—18% versus 11%, respectively—and a higher percentage of patients—31% versus 21%—had early symptom resolution, within 24 hours after stroke.

Patients in this study were treated with tissue plasminogen activator (t-PA), a mainstay medication delivered intravenously (IV) in stroke cases. The drug dissolves the clot in an artery that is blocking to the brain, making treatment time critical.

"While this is known to improve , how many patients fully recover afterward wasn't clear from prior research," said lead author Dr. Babak Benjamin Navi, associate professor, vice chair for hospital neurology services and chief of stroke and hospital neurology, in the neurology department at Weill Cornell Medicine. He is also acting medical director of the MSU, operated by New York-Presbyterian, in collaboration with Weill Cornell Medicine, Columbia University Irving Medical Center, and the Fire Department of New York.

Every minute counts when treating stroke

"On average, the faster you treat someone, the more likely you are to have a good functional outcome because you're able to preserve more ," Dr. Navi said, who is also associate professor of neuroscience at the Feil Family Brain and Mind Research Institute at Weill Cornell and the medical director of the stroke center at New York-Presbyterian/Weill Cornell Medical Center. "The brain can only sustain reduced blood flow for so long before permanent injury develops."

Using multicenter trial data from 2014-2020, the researchers evaluated 1,009 patients: 644 received t-PA in an MSU, and 365 received EMS care. Overall, patients received t-PA at a median interval of 87 minutes after the onset of stroke symptoms. The study found that with t-PA treatment in this time frame, about one in four patients who had a suspected stroke recovered within 24 hours and one in six averted a stroke with no demonstrable trace of brain injury on an MRI.

The outcome improved for patients treated by an MSU since the time from symptom onset to treatment was 37 minutes faster than for EMS care, meaning many more patients received vital t-PA within the crucial first hour. MSU care further increased the odds of averting a stroke with nearly one-third of recovering to normal within 24 hours.

In addition, the researchers found other factors that contributed to better patient outcome: treatment within the first 45 minutes, younger age, being female, history of high cholesterol, , lower stroke severity and no blockage of large blood vessels.

Bringing the treatment to the patient

Every 40 seconds, someone in the United States has a stroke, according to the American Heart Association. This study highlights the need for optimizing stroke systems of care, Dr. Navi said. Further expediting the delivery of t-PA through MSUs should be a priority to increase the proportion of averted strokes.

Dr. Navi is also hoping that Medicare will assign MSU services a billing code in the near future so that it can be embedded within stroke systems of care and become a financially viable model.

Currently, he is working with researchers from UTHealth Houston on a study to evaluate the cost effectiveness of MSUs, which should be published next year. "Such studies will hopefully lead to a shift in regulations and reimbursements, and how MSUs are led, managed and integrated within emergency medical services," he said.

Co-principal investigators for the BEST-MSU trial, which produced the data for this analysis, were Dr. James C. Grotta, director of research at the Clinical Innovation and Research Institute at Memorial Hermann—Texas Medical Center and director of the Mobile Stroke Unit Consortium; and Dr. Jose-Miguel Yamal, department of biostatistics at UTHealth Houston School of Public Health.

Also, contributing to this effort was Dr. John Volpi, director of the Eddy Scurlock Stroke Center Houston Methodist Stanley H. Appel Department of Neurology and associate professor of clinical neurology in neurology at Weill Cornell Medicine.

More information: Babak B. Navi et al, Strokes Averted by Intravenous Thrombolysis: A Secondary Analysis of a Prospective, Multicenter, Controlled Trial of Mobile Stroke Units, Annals of Neurology (2023). DOI: 10.1002/ana.26816

Journal information: Annals of Neurology
Citation: Mobile stroke units increase odds of averting stroke (2023, October 26) retrieved 27 February 2024 from https://medicalxpress.com/news/2023-10-mobile-odds-averting.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Mobile stroke units could expedite treatment and improve patient outcomes in urban areas

2 shares

Feedback to editors