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C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells

gene
Credit: Pixabay/CC0 Public Domain

A new editorial perspective titled "C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells" has been published in Oncotarget.

In this new paper, researcher Karl-Heinz Klempnauer from Westfälische-Wilhelms-Universität discusses recent studies on the role of transcription factor MYB in (AML). MYB has been identified as a key regulator of a transcriptional program for self-renewal of AML cells.

The MYB gene initially attracted attention as the progenitor of a retrovirally-transduced oncogene that induces a myeloid leukemia in chickens. MYB encodes a transcription factor with essential roles in the development of the hematopoietic system and the proliferation and differentiation of hematopoietic progenitor cells. Subsequent work identified MYB also as a crucial player in the development and maintenance of leukemia in humans.

"Recent work summarized here has now highlighted the CCAAT-box/enhancer binding protein beta (C/EBPβ) as an essential factor and potential therapeutic target that cooperates with MYB and coactivator p300 in the maintenance of the leukemic cells," the paper states.

Credit: Impact Journals LLC

More information: Karl-Heinz Klempnauer, C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells, Oncotarget (2023). DOI: 10.18632/oncotarget.28377

Journal information: Oncotarget
Provided by Impact Journals LLC
Citation: C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells (2023, November 13) retrieved 25 February 2024 from https://medicalxpress.com/news/2023-11-cebp-cooperates-myb-oncogenic-aml.html
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