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Made-to-order diagnostic tests may be on the horizon: Researchers invent lab on a chip that can be 3D-printed in minutes

Made-to-order diagnostic tests may be on the horizon, says new research
Digital manufacturing (DM) of functional capillaric circuits (CCs) using an intrinsically hydrophilic ink (CCInk). a) 1) Additive manufacturing of CCs from a digital design file using a light engine and layer-by-layer vat photopolymerization. 2) Removal of uncured CCInk under a stream of compressed air (<1 min). 3) Functional CC loaded with reagents and primed to execute the structurally encoded (i.e., pre-programmed) capillary flow events following the addition of the triggering solution. b) CCInk composition including polyethyleneglycol diacrylate (PEGDA-250) monomer, acrylic acid (AA) additive to tune hydrophilicity, a photinitiator (TPO), and a photoadsorber (ITX). Credit: Advanced Materials (2023). DOI: 10.1002/adma.202303867

McGill University researchers have made a breakthrough in diagnostic technology, inventing a "lab on a chip" that can be 3D-printed in just 30 minutes. The chip has the potential to make on-the-spot testing widely accessible.

As part of a recent study, the results of which were published in the journal Advanced Materials, the McGill team developed capillaric chips that act as miniature laboratories. Unlike other computer microprocessors, these chips are and require no external power source; a simple paper strip suffices. They function through , the very phenomena by which a spilled liquid on the kitchen table spontaneously wicks into the paper towel used to wipe it up.

"Traditional diagnostics require peripherals, while ours can circumvent them. Our diagnostics are a bit what the was to traditional desktop computers that required a separate monitor, keyboard and to operate," explains Prof. David Juncker, Chair of the Department of Biomedical Engineering at McGill and senior author on the study.

At-home testing became crucial during the COVID-19 pandemic. But have limited availability and can only drive one liquid across the strip, meaning most diagnostics are still done in central labs. Notably, the capillaric chips can be 3D-printed for various tests, including COVID-19 antibody quantification.

The study brings 3D-printed home diagnostics one step closer to reality, though some challenges remain, such as regulatory approvals and securing necessary test materials. The team is actively working to make their technology more accessible, adapting it for use with affordable 3D printers. The innovation aims to speed up diagnoses, enhance patient care, and usher in a new era of accessible testing.

"This advancement has the capacity to empower individuals, researchers, and industries to explore new possibilities and applications in a more cost-effective and user-friendly manner," says Prof. Juncker. "This innovation also holds the potential to eventually empower with the ability to rapidly create tailored solutions for specific needs right at the point-of-care."

More information: Vahid Karamzadeh et al, Digital Manufacturing of Functional Ready‐to‐Use Microfluidic Systems, Advanced Materials (2023). DOI: 10.1002/adma.202303867

Journal information: Advanced Materials
Provided by McGill University
Citation: Made-to-order diagnostic tests may be on the horizon: Researchers invent lab on a chip that can be 3D-printed in minutes (2023, November 29) retrieved 21 February 2024 from https://medicalxpress.com/news/2023-11-made-to-order-diagnostic-horizon-lab-chip.html
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