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Mean platelet volume linked to mortality in peritoneal dialysis patients

Mean platelet volume linked to mortality in peritoneal dialysis patients

For patients treated with peritoneal dialysis (PD), mean platelet volume (MPV) is associated with all-cause mortality and cardiovascular mortality, according to a study published online Nov. 8 in BMC Cardiovascular Disorders.

Jianghai Wang, from the Dongying People's Hospital in China, and colleagues estimated the relationship between MPV and all-cause and cardiovascular mortality among 1,322 treated with PD. The associations were assessed in three models: Model 1 was unadjusted; model 2 was adjusted for age, gender, Charlson comorbidity index, diabetes, hypertension, premorbid cardiovascular diseases, body mass index, and antiplatelet medication; and model 3 had further adjustment for hemoglobin, albumin, triglyceride, , and low-density lipoprotein cholesterol.

A total of 360 deaths were recorded during a median follow-up of 50 months. The researchers found that the risk for all-cause mortality was considerably higher among patients with MPV ≥10.2 fL in all three models (hazard ratios, 0.68, 0.70, and 0.73, respectively). The risk for cardiovascular mortality was also higher among patients with MPV ≥10.2 fL in models 1, 2, and 3 (hazard ratios, 0.63, 0.66, and 0.69, respectively).

"Our findings suggest that high levels of MPV (MPV ≥10.2 fL) is an independent hazards and biological marker for all-cause and in patients treated with PD," the authors write.

More information: Jianghai Wang et al, Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients, BMC Cardiovascular Disorders (2023). DOI: 10.1186/s12872-023-03551-x

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Citation: Mean platelet volume linked to mortality in peritoneal dialysis patients (2023, November 24) retrieved 3 March 2024 from https://medicalxpress.com/news/2023-11-platelet-volume-linked-mortality-peritoneal.html
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