This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

reputable news agency

proofread

CVD mortality similar with diuretic, ACE inhibitor, or calcium channel blocker

CVD mortality similar with diuretic, ACE inhibitor, or calcium channel blocker

For patients with hypertension and at least one other coronary heart disease risk factor, cardiovascular disease (CVD) mortality is similar for those receiving a thiazide-type diuretic, calcium channel blocker (CCB), or angiotensin-converting enzyme (ACE) inhibitor, according to a study published online Dec. 4 in JAMA Network Open.

Jose-Miguel Yamal, Ph.D., from The University of Texas Health Science Center at Houston, and colleagues randomly assigned participants aged 55 years or older with a diagnosis of hypertension and at least one other coronary heart disease risk factor to receive a thiazide-type diuretic (15,002), a CCB (8,898), or an ACE inhibitor (8,904). Participants were followed for all-cause due to CVD, and a subgroup of 22,754 participants were followed for fatal or nonfatal CVD.

The researchers found that CVD mortality rates were 23.7, 21.6, and 23.8 per 100 persons in the diuretic, CCB, and ACE inhibitor groups, respectively, at 23 years after randomization. For most secondary outcomes, the long-term risks were similar among the three groups. The ACE inhibitor group had increased risks for and for combined fatal and nonfatal hospitalized stroke compared with the diuretic group (adjusted hazard ratios, 1.19 and 1.11, respectively).

"Angiotensin-converting enzyme inhibitors were associated with an increased risk of stroke outcomes (11 percent increased risk of combined fatal and nonfatal hospitalized stroke) compared with diuretics, and this effect persisted well beyond the trial period," the authors write.

More information: Jose-Miguel Yamal et al, Mortality and Morbidity Among Individuals With Hypertension Receiving a Diuretic, ACE Inhibitor, or Calcium Channel Blocker, JAMA Network Open (2023). DOI: 10.1001/jamanetworkopen.2023.44998

Journal information: JAMA Network Open

Copyright © 2023 HealthDay. All rights reserved.

Citation: CVD mortality similar with diuretic, ACE inhibitor, or calcium channel blocker (2023, December 4) retrieved 4 March 2024 from https://medicalxpress.com/news/2023-12-cvd-mortality-similar-diuretic-ace.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Pediatric case fatality rates increased from 2011 to 2021

7 shares

Feedback to editors