This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

reputable news agency

proofread

Recommendations for tests to support diagnosis of syphilis

Recommendations developed for tests to support diagnosis of syphilis

In a report issued by the U.S. Centers for Disease Control and Prevention and published online Feb. 8 in Morbidity and Mortality Weekly Report, recommendations are presented for tests that can support a diagnosis of syphilis, including identification of Treponema pallidum.

John R. Papp, Ph.D., from the CDC in Atlanta, and colleagues note that depending on whether the tests detect antibodies that are broadly reactive to lipoidal antigens shared by both host and T. pallidum or antibodies specific to T. pallidum, the for T. pallidum can be categorized into nontreponemal and treponemal tests, respectively.

To help differentiate between an untreated infection or a past infection that has been successfully treated, both types of tests must be used in conjunction. Newer serological tests allow for laboratory automation but have to be used in an algorithm, which can include older manual serological tests. Direct detection of T. pallidum is continuing to evolve from microscopic examination of materials from lesions to molecular detection of T. pallidum.

"Additional point-of-care tests and data are needed to increase understanding of their performance in clinical and outreach settings," the authors write.

"Additional areas needed for research include well-designed prospective studies on point-of-care test performance in the context of screening algorithms, special patient populations, linkage to treatment and care, and cost-benefits so that recommendations can be made regarding performance and use in the United States."

More information: John R. Papp et al, CDC Laboratory Recommendations for Syphilis Testing, United States, 2024, MMWR. Recommendations and Reports (2024). DOI: 10.15585/mmwr.rr7301a1

Copyright © 2024 HealthDay. All rights reserved.

Citation: Recommendations for tests to support diagnosis of syphilis (2024, February 13) retrieved 13 June 2024 from https://medicalxpress.com/news/2024-02-diagnosis-syphilis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Graph convolutional network can classify schizophrenia

0 shares

Feedback to editors