This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:


peer-reviewed publication

reputable news agency


Fecal occult blood testing tied to reduction in colorectal cancer mortality

Fecal occult blood testing tied to reduction in colorectal cancer mortality

Routine screening with fecal occult blood testing (FOBT) is associated with a decrease in colorectal cancer (CRC) mortality, according to a study published online Feb. 27 in JAMA Network Open.

Johannes Blom, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleagues evaluated cancer-specific mortality associated with early versus late or no invitation for routine CRC screening using FOBT. The analysis included 203,670 individuals invited early and 175,778 invited late or not at all (control group).

The researchers found that the mean screening participation rate was 63.3 percent during a maximum of 14 years of follow-up. In the early invitation group, there were 834 CRC deaths in more than 2.19 million person-years versus 889 CRC deaths in roughly 2.25 million person-years in the control group, yielding a lower risk for CRC mortality with CRC screening (rate ratio, 0.86), as well as a lower risk for excess (rate ratio, 0.84).

"Our results have an important public health implication in suggesting that organized population-based CRC screening with FOBT has the potential to save lives worldwide," the authors write.

"By using fecal immunochemical testing as a screening test, with a higher sensitivity and participation rate than guaiac-based FOBT, more lives could be saved, but adherence to prompt follow-up colonoscopies after a positive test result is essential."

More information: Johannes Blom et al, Routine Fecal Occult Blood Screening and Colorectal Cancer Mortality in Sweden, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.0516

Journal information: JAMA Network Open

Copyright © 2024 HealthDay. All rights reserved.

Citation: Fecal occult blood testing tied to reduction in colorectal cancer mortality (2024, March 5) retrieved 19 May 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Fecal occult blood test may improve CRC outcomes in some


Feedback to editors