This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

proofread

Study investigates systemic thrombolysis in patients with liver cirrhosis

liver cirrhosis
Credit: Pixabay/CC0 Public Domain

The prevalence of Portal Vein Thrombosis (PVT) varies significantly at different stages of liver disease: 10% in compensated patients, 17% in decompensated patients, 9% in those with acute decompensated cirrhosis, and 2–26% in post-liver transplant patients.

A recent study aimed to evaluate the effectiveness and safety of systemic thrombolysis for acute portal vein thrombosis in patients with . The paper is published in The Open Biomarkers Journal.

Ten compensated cirrhotic patients with acute portal vein thrombosis were examined using abdominal ultrasound with color Doppler and contrast-enhanced CT scans. All patients received continuous intravenous infusions of recombinant tissue plasminogen activator (r-tPA) and low molecular weight heparin (LMWH) for up to 7 days.

Patients were monitored for clinical improvement and radiological changes using abdominal ultrasound with color Doppler and contrast-enhanced CT scans.

The was well-tolerated by all patients. After seven days, six patients (60%) had full recanalization of the portal vein, three patients (30%) had partial recanalization, and one patient (10%) had no recanalization.

Preliminary data suggest that systemic thrombolytic therapy combined with low molecular weight heparin is a safe and effective treatment for PVT over a short period, with no significant side effects.

More information: Samah Soliman et al, Systemic Thrombolysis of Acute Portal Venous System Thrombosis in Patients with Liver Cirrhosis: A Pilot Study, The Open Biomarkers Journal (2024). DOI: 10.2174/0118753183285252240329035743

Provided by Bentham Science Publishers
Citation: Study investigates systemic thrombolysis in patients with liver cirrhosis (2024, May 24) retrieved 16 June 2024 from https://medicalxpress.com/news/2024-05-thrombolysis-patients-liver-cirrhosis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Guidance issued for hepatic, mesenteric circulation disorders

0 shares

Feedback to editors