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Study investigates systemic thrombolysis in patients with liver cirrhosis

liver cirrhosis
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The prevalence of Portal Vein Thrombosis (PVT) varies significantly at different stages of liver disease: 10% in compensated patients, 17% in decompensated patients, 9% in those with acute decompensated cirrhosis, and 2–26% in post-liver transplant patients.

A recent study aimed to evaluate the effectiveness and safety of systemic thrombolysis for acute portal vein thrombosis in patients with . The paper is published in The Open Biomarkers Journal.

Ten compensated cirrhotic patients with acute portal vein thrombosis were examined using abdominal ultrasound with color Doppler and contrast-enhanced CT scans. All patients received continuous intravenous infusions of recombinant tissue plasminogen activator (r-tPA) and low molecular weight heparin (LMWH) for up to 7 days.

Patients were monitored for clinical improvement and radiological changes using abdominal ultrasound with color Doppler and contrast-enhanced CT scans.

The was well-tolerated by all patients. After seven days, six patients (60%) had full recanalization of the portal vein, three patients (30%) had partial recanalization, and one patient (10%) had no recanalization.

Preliminary data suggest that systemic thrombolytic therapy combined with low molecular weight heparin is a safe and effective treatment for PVT over a short period, with no significant side effects.

More information: Samah Soliman et al, Systemic Thrombolysis of Acute Portal Venous System Thrombosis in Patients with Liver Cirrhosis: A Pilot Study, The Open Biomarkers Journal (2024). DOI: 10.2174/0118753183285252240329035743

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Citation: Study investigates systemic thrombolysis in patients with liver cirrhosis (2024, May 24) retrieved 25 June 2024 from https://medicalxpress.com/news/2024-05-thrombolysis-patients-liver-cirrhosis.html
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