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Review explores potential of senescent cell-derived vaccines for cancer and aging
A new review paper titled "Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?" has been published in Aging.
Two recent seminal works have untangled the intricate role of tumor-associated senescent cells in cancer progression or regression by guiding our immune system against cancer cells. The characterization of these unique yet diverse cell populations should be considered, particularly when contemplating the use of senolytics, which are drugs that selectively eliminate senescent cells, in a cancer framework.
In this new review, researchers João Pessoa, Sandrina Nóbrega-Pereira, and Bruno Bernardes de Jesus from the University of Aveiro describe the current knowledge in this field.
The researchers write, "In particular, we will discuss how the presence of senescent cells in tumors could be used as a therapeutic target in immunogenic cancers and how we may hypothetically design an adaptive anti-aging vaccine."
More information: João Pessoa et al, Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?, Aging (2024). DOI: 10.18632/aging.205975
